ArticleAddiction biology2020
Impaired decision making following escalation of cocaine self-administration predicts vulnerability to relapse in rats.
Article in Addiction biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Dissociation of decision-making from escalated drug intake within a long-access model.Behavioural brain research · 2026Article
- Chemogenetic modulation of the prelimbic cortex to the nucleus accumbens core pathway reduces cocaine-induced increase of risk preference.Translational psychiatry · 2026Article
- Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Neurobehavioral Precursors of Compulsive Cocaine Seeking in Dual Frontostriatal Circuits.Biological psychiatry global open science · 2024Article
- Motor impulsivity but not risk-related impulsive choice is associated to drug intake and drug-primed relapse.Frontiers in behavioral neuroscience · 2023Article
- Regulation of sex differences in risk-based decision making by gonadal hormones: Insights from rodent models.Behavioural processes · 2022Review
- Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders.Journal of neuroscience research · 2022Review
- Chronic cocaine causes age-dependent increases in risky choice in both males and females.Behavioral neuroscience · 2022Article
- Animal Models of the Behavioral Symptoms of Substance Use Disorders.Cold Spring Harbor perspectives in medicine · 2021Review
- Advances in understanding meso-cortico-limbic-striatal systems mediating risky reward seeking.Journal of neurochemistry · 2021Review
- Adolescent-onset vs. adult-onset cocaine use: Impact on cognitive functioning in animal models and opportunities for translation.Pharmacology, biochemistry, and behavior · 2020Review
- Impaired decision making following escalation of cocaine self-administration predicts vulnerability to relapse in rats.Addiction biology · 2020Article
- Effects of exposure to chronic uncertainty and a sensitizing regimen of amphetamine injections on locomotion, decision-making, and dopamine receptors in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Challenges and Opportunities in Animal Models of Gambling-like Behavior.Current opinion in behavioral sciences · 2020Article
- Understanding Addiction Using Animal Models.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Impairments in cost-benefit decision making represent a cardinal feature of drug addiction. However, whether these alterations predate drug exposure, thereby contributing to facilitating loss of control over drug intake, or alternatively arise as a result of drug use and subsequently confer vulnerability to relapse has yet to be determined. Male Sprague-Dawley rats were trained to self-administer (SA) cocaine during 19 daily long-access (12-h) sessions; conditions reliably shown to promote escalation. One week after cocaine SA, rats underwent an extinction/relapse test immediately followed by conditioned stimuli-, stress-, and drug-primed reinstatement challenges. The influence of escalated cocaine intake on decision making was measured over time by four test sessions of a rodent analogue of the Iowa Gambling Task (rGT), once prior to cocaine exposure and then 1 day, 1 week, and 1 month after the last SA session. Substantial individual variability was observed in the influence of escalated cocaine SA on decision-making performance. A subset of rats displayed pronounced deficits, while others showed unaffected or even improved performance on the rat Gambling Task (rGT) 24 hours after the last SA session. When challenged with a relapse test after 1 week of forced abstinence, animals that showed impaired decision making following SA displayed an increased propensity to respond for cocaine under extinction. These data suggest that decision-making deficits in individuals with drug addiction are not antecedent to-but arise as a consequence of-drug exposure. Moreover, these data indicate that susceptibility to the deleterious effects of drugs on decision making confers vulnerability toward relapse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.