Evidence map›Paper›PMID 30847967›Full record

ArticleMagnetic resonance in medicine2019

Mapping and correcting hyperpolarized magnetization decay with radial keyhole imaging.

Peter J Niedbalski, Matthew M Willmering, Scott H Robertson, Matthew S Freeman, Wolfgang Loew, Randy O Giaquinto, Christopher Ireland, Ronald G Pratt, Charles L Dumoulin, Jason C Woods and 1 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Analytical corrections for BMagnetic resonance in medicine · 2024
    Article
  6. BMagnetic resonance in medicine · 2023
    Article
  7. Diffusion weighted hyperpolarizedMagnetic resonance in medicine · 2023
    Article
  8. Bias field correction in hyperpolarizedMagnetic resonance in medicine · 2022
    Article
  9. Article
  10. Improved preclinical hyperpolarizedNMR in biomedicine · 2021
    Article
  11. In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021
    Review
  12. Article
  13. Preclinical hyperpolarizedNMR in biomedicine · 2020
    Article
  14. Improved pulmonaryMagnetic resonance in medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peter J NiedbalskiCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-0528-2508
Matthew M WillmeringCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-4356-9622
Scott H RobertsonClinical Imaging Physics Group, Department of Radiology, Duke University Medical Center, Durham, North Carolina.
Matthew S FreemanCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Wolfgang LoewImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Randy O GiaquintoImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Christopher IrelandImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Ronald G PrattImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Charles L DumoulinImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jason C WoodsCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Zackary I ClevelandCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Funding

Editing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
Validating Quantitative Magnetic Resonance Imaging Biomarkers of Idiopathic Pulmonary FibrosisR01HL143011 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2019 to 2023
$3.7M
A Phase III Trial to Validate HP 129Xe MRI as a Functional Pulmonary Biomarker in Pediatric Lung DiseaseR44HL123299 · NHLBI · POLAREAN, INC. · PI EMAMI, KIARASH · 2017 to 2019
$3.0M
Time-Resolved 129Xe Ventilation-Perfusion MRI in Models of Acute Lung InjuryR00HL111217 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2015 to 2017
$728k
NHLBI NIH HHS R00 HL111217NHLBI NIH HHS R01 HL143011NHLBI NIH HHS R44 HL123299NHLBI NIH HHS T32 HL007752NHLBI NIH HHS U01 HL134745
6 · The paper itself

Abstract

purposeHyperpolarized (HP) media enable biomedical imaging applications that cannot be achieved with conventional MRI contrast agents. Unfortunately, quantifying HP images is challenging, because relaxation and radio-frequency pulsing generate spatially varying signal decay during acquisition. We demonstrate that, by combining center-out k-space sampling with postacquisition keyhole reconstruction, voxel-by-voxel maps of regional HP magnetization decay can be generated with no additional data collection. THEORY AND

methodsDigital phantom, HP

resultsMean, keyhole-derived decay terms showed excellent agreement with the decay used in simulations (R

conclusionsWe have demonstrated that center-out trajectories combined with keyhole reconstruction can be used to map regional HP signal decay and to quantitatively correct images. This approach may be used to improve the accuracy of quantitative measures obtained from hyperpolarized media. Although validated with gaseous HP

Indexed as

Signal Processing, Computer-AssistedAdolescentAdultChildChild, PreschoolContrast MediaCystic FibrosisFemaleHumansImage Processing, Computer-AssistedLungMagnetic Resonance ImagingMalePhantoms, ImagingXenon IsotopesContrast MediaXenon Isotopes129XehyperpolarizationkeyholepulmonaryradialUTEventilation

Identifiers

PMID30847967
PMCPMC6491256

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.