ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Absolute myocardial blood flows derived by dynamic CZT scan vs invasive fractional flow reserve: Correlation and accuracy.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Diagnostic accuracy of dynamic CZT-SPECT in coronary artery disease. A systematic review and meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Pooled it
- The prognostic value of quantitative myocardial blood flow and flow reserve by dynamic CZT-SPECT for major adverse cardiovascular events.European journal of nuclear medicine and molecular imaging · 2026Article
- Associations of AI-derived coronary CT angiography features with CZT-SPECT coronary flow reserve and FFR-CT.Frontiers in cardiovascular medicine · 2026Article
- Diagnostic and prognostic value of myocardial flow reserve quantification with single photon emission computed tomography - a systematic review and meta-analysis.EJNMMI research · 2025Article
- Coronary Flow Reserve Measured by Myocardial Perfusion Imaging in Patients Following Percutaneous Coronary Intervention.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- Accuracy of a whole-body single-photon emission computed tomography with a thallium-bromide detector: Verification via Monte Carlo simulations.Medical physics · 2025Article
- Short-term changes in myocardial perfusion of the predominant donor vessel after percutaneous coronary intervention for chronic total occlusion.Quantitative imaging in medicine and surgery · 2025Article
- Comparison of global and regional myocardial blood flow quantification using dynamic solid-state detector SPECT and Tc-99 m-sestamibi or Tc-99 m-tetrofosmin in a routine clinical setting.The international journal of cardiovascular imaging · 2025Article
- Recent Progress in Myocardial Perfusion Imaging Techniques.Nuclear medicine and molecular imaging · 2024Review
- Intraoperative Prediction of Coronary Graft Failure Based on Transit Time Flow Measurement: A PRELIMINARY STUDY.Diagnostics (Basel, Switzerland) · 2024Article
- The Influence of Kinetic Models and Attenuation Correction on Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography (CZT SPECT)-Derived Myocardial Blood Flow and Reserve: Correlation with Invasive Angiography Data.Journal of clinical medicine · 2024Article
- The diagnostic role of resting myocardial blood flow in STEMI patients after revascularization.Frontiers in cardiovascular medicine · 2024Article
- SPECT myocardial blood flow quantitation for the detection of angiographic stenoses with cardiac-dedicated CZT SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Measuring myocardial blood flow using dynamic myocardial perfusion SPECT: artifacts and pitfalls.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Quantitative flow ratio derived pullback pressure gradient and CZT-SPECT measured longitudinal flow gradient for hemodynamically significant coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- SPECT measurements of myocardial blood flow and flow reserve: from development to implementation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Role of nuclear cardiology in diagnosis and risk stratification of coronary microvascular disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Prognostic value of myocardial flow reserve derived by quantitative SPECT for patients with intermediate coronary stenoses.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A preliminary study of dobutamine myocardial flow reserve onAnnals of nuclear medicine · 2023Article
- Coronary Microvascular Dysfunction: Features and Prognostic Value.Journal of clinical medicine · 2023Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo define the diagnostic power of absolute myocardial blood flow (MBF) evaluation on dynamic CZT imaging in intermediate risk patients in comparison with invasive coronary angiography (ICA) and fractional flow reserve (FFR).
methodsTwenty-three stable CAD patients underwent one-day dynamic rest-stress 99mTc-Sestamibi myocardial perfusion imaging by CZT camera. Stress and rest MBF values were calculated semi-automatically using a net retention model by Leppo. Coronary flow reserve (CFR) and flow difference (FD) [MBF stress - MBF rest] were also estimated. A total of 28 vessels were functionally quantified with FFR: 19 (68%) vessels with a stenosis ≥ 70% and 9 (32%) with < 70% stenotic lesions.
resultsThe mean global MBFs at rest and during stress were 0.36 (IQR 0.33-0.54) mL/min/g and 0.67 (IQR 0.55-0.81) mL/min/g, respectively, with an average CFR of 1.80 (IQR 1.35-2.24). Moderate correlations between stenosis severity and FFR (r = 0.45; P = .01), stress MBF (r = -0.46; P = .01) and FD (r = -0.37; P = .04) were detected. FFR abnormalities were best predicted by absolute stress MBF, CFR and FD with values of ≤ 0.54 mL/min/g (sensitivity 61.5%; specificity 93.3%), ≤ 1.48 (sensitivity 69.2%; specificity 93.3%) and ≤ 0.18 mL/min/g (sensitivity 69.2%; specificity 100%), respectively.
conclusionsThe values of stress MBF, CFR and FD obtained through dynamic CZT acquisitions compare well with invasive FFR. The clinical use of dynamic acquisition of myocardial perfusion imaging by CZT may help cardiologist in the detection of hemodynamically significant CAD.
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