Evidence map›Paper›PMID 30847754›Full record

ArticleJournal of natural medicines2019

Flavonoids isolated from the flowers of Pulsatilla flavescens and their anti-piroplasm activity.

Dorj Ganchimeg, Badarch Batbold, Toshihiro Murata, Bekh-Ochir Davaapurev, Tserendorj Munkhjargal, Bumduuren Tuvshintulga, Keisuke Suganuma, Ikuo Igarashi, Buyanmandakh Buyankhishig, Kenroh Sasaki and 2 more

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Myrrh OilPathogens (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Dorj GanchimegSchool of Engineering and Applied Sciences, National University of Mongolia, P.O.B.-617/46A, Ulaanbaatar, 14201, Mongolia.
Badarch BatboldSchool of Engineering and Applied Sciences, National University of Mongolia, P.O.B.-617/46A, Ulaanbaatar, 14201, Mongolia.
Toshihiro MurataDepartment of Pharmacognosy, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai, 981-8558, Japan. murata-t@tohoku-mpu.ac.jp.ORCID http://orcid.org/0000-0001-7778-3822
Bekh-Ochir DavaapurevSchool of Engineering and Applied Sciences, National University of Mongolia, P.O.B.-617/46A, Ulaanbaatar, 14201, Mongolia.
Tserendorj MunkhjargalNational Research Center of Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, 080-8555, Japan.
Bumduuren TuvshintulgaNational Research Center of Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, 080-8555, Japan.
Keisuke SuganumaNational Research Center of Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, 080-8555, Japan.
Ikuo IgarashiNational Research Center of Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, 080-8555, Japan.
Buyanmandakh BuyankhishigDepartment of Pharmacognosy, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai, 981-8558, Japan.
Kenroh SasakiDepartment of Pharmacognosy, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai, 981-8558, Japan.
Dulamjav BatsurenInstitute of Chemistry and Chemical Technology, Mongolian Academy of Science, Ulaanbaatar, 210351, Mongolia.
Javzan BatkhuuSchool of Engineering and Applied Sciences, National University of Mongolia, P.O.B.-617/46A, Ulaanbaatar, 14201, Mongolia.
National University of Mongolia · MNObihiro University of Agriculture and Veterinary Medicine · JPTohoku Medical and Pharmaceutical University · JPMongolian Academy of Sciences · MNMongolian University of Life Sciences · MNPskov State University · RU

Funding

Cooperative Research Grant from the National Research Center for Protozoan Diseases (29-joint-6Cooperative Research Grant from the National Research Center for Protozoan Diseases 30-joint-11)Grant for Advanced Research at National University of Mongolia 2019Grant-in-aid project from Mongolian Foundation of Science and Technology (2018/58)
6 · The paper itself

Abstract

Pulsatilla species are known as "Yargui", and their flowers are traditionally used in Mongolia as a tonic and for the treatment of inflammatory diseases. By chemical investigation of P. flavescens flowers, 21 flavonoids, including a new chalcone C-glucoside, chalconaringenin 2'-O-β-D-glucopyranosyl-5'-β-D-glucopyranoside, and two new flavanone C-glucosides, (2R)- and (2S)-naringenin 8-β-D-glucopyranosyl-4'-O-β-D-glucopyranoside, were isolated. The absolute configurations of the seven flavanone glucosides were elucidated by ECD spectra. For the isolated compounds, inhibitory activity against Babesia caballi and Theileria equi, which cause fatal diseases in horses, was estimated. Although most of the isolated chalcone and flavanone derivatives did not show any anti-piroplasm activity, all the isolated flavone and flavonol derivatives showed moderate effects against B. caballi and/or T. equi.

Indexed as

FlavonoidsFlowersHumansMolecular StructurePulsatillaFlavonoidsAnti-piroplasma activityFlavonoidsPulsatilla flavescensYargui

Identifiers

PMID30847754
OpenAlexW2921572711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.