Evidence map›Paper›PMID 30847690›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2019

Imaging of changes in copper trafficking and redistribution in a mouse model of Niemann-Pick C disease using positron emission tomography.

Julia Baguña Torres, Zilin Yu, Jayanta Bordoloi, Kavitha Sunassee, David Smith, Claire Smith, Oscar Chen, Rupert Purchase, Karin Tuschl, John Spencer and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Organ Weights inInternational journal of molecular sciences · 2022
    Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Julia Baguña TorresSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.ORCID 0000-0001-8621-3549
Zilin YuSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Jayanta BordoloiSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.ORCID 0000-0002-6547-9476
Kavitha SunasseeSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.ORCID 0000-0003-2726-333X
David SmithDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Claire SmithDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Oscar ChenDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Rupert PurchaseDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QJ, UK.
Karin TuschlMRC Centre for Developmental Neurobiology IoPPN, King's College London, London, SE1 1UL, UK.
John SpencerDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QJ, UK.ORCID 0000-0001-5231-8836
Frances PlattDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.ORCID 0000-0001-7614-0403
Philip J BlowerSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK. philip.blower@kcl.ac.uk.ORCID 0000-0001-6290-1590
St Thomas' Hospital · GBUniversity of Oxford · GBUniversity of Sussex · GBKing's College London · GB

Funding

Cancer Research UK 16463Department of HealthMedical Research CouncilWellcome Trust 202834/Z/16/ZWellcome Trust WT 084052/Z/07/ZWellcome Trust WT088641/Z/09/Z
6 · The paper itself

Abstract

Niemann-Pick C disease (NPC) is an autosomal recessive lysosomal storage disorder resulting from mutations in the NPC1 (95% of cases) or NPC2 genes. Disturbance of copper homeostasis has been reported in NPC1 disease. In this study we have used whole-body positron emission tomography (PET) and brain electronic autoradiography with copper-64 (

Indexed as

Disease Models, AnimalPositron-Emission TomographyAnimalsCoordination ComplexesCopper RadioisotopesInjections, IntravenousMiceMice, Inbred BALB CMice, KnockoutMice, TransgenicNiemann-Pick Disease, Type CThiosemicarbazonesCoordination ComplexesCopper-64Copper Radioisotopesglyoxal-bis(4-methylthiosemicarbazonato)copper(II)ThiosemicarbazonesAutoradiographyCopper-64Copper dyshomeostasisNiemann-Pick CPositron emission tomography

Identifiers

PMID30847690
PMCPMC6437134
OpenAlexW2921130386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.