Evidence map›Paper›PMID 30847659›Full record

ArticleThe international journal of cardiovascular imaging2019

Multimodality imaging for real-time image-guided left ventricular lead placement during cardiac resynchronization therapy implantations.

Odette A E Salden, Hans T van den Broek, Wouter M van Everdingen, Firdaus A A Mohamed Hoesein, Birgitta K Velthuis, Pieter A Doevendans, Maarten-Jan Cramer, Anton E Tuinenburg, Paul Leufkens, Frebus J van Slochteren and 1 more

Abstract read
In one paragraph

Article in The international journal of cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Targeted left ventricular lead positioning to the site of latest activation in cardiac resynchronization therapy: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. [Left ventricular electrode placement in cardiac resynchronization therapy].Herzschrittmachertherapie & Elektrophysiologie · 2025
    Article
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  11. Feasibility and potential benefit of pre-procedural CMR imaging in patients with ischaemic cardiomyopathy undergoing cardiac resynchronisation therapy.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Odette A E SaldenDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands. o.a.e.salden@umcutrecht.nl.ORCID http://orcid.org/0000-0003-1942-0331
Hans T van den BroekDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
Wouter M van EverdingenDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
Firdaus A A Mohamed HoeseinDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Birgitta K VelthuisDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Pieter A DoevendansDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
Maarten-Jan CramerDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
Anton E TuinenburgDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
Paul LeufkensCART-Tech B.V, Utrecht, The Netherlands.
Frebus J van SlochterenDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
Mathias MeineDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was performed to evaluate the feasibility of intra-procedural visualization of optimal pacing sites and image-guided left ventricular (LV) lead placement in cardiac resynchronization therapy (CRT). In fifteen patients (10 males, 68 ± 11 years, 7 with ischemic cardiomyopathy and ejection fraction of 26 ± 5%), optimal pacing sites were identified pre-procedurally using cardiac imaging. Cardiac magnetic resonance (CMR) derived scar and dyssynchrony maps were created for all patients. In six patients the anatomy of the left phrenic nerve (LPN) and coronary sinus ostium was assessed via a computed tomography (CT) scan. By overlaying the CMR and CT dataset onto live fluoroscopy, aforementioned structures were visualized during LV lead implantation. In the first nine patients, the platform was tested, yet, no real-time image-guidance was implemented. In the last six patients real-time image-guided LV lead placement was successfully executed. CRT implant and fluoroscopy times were similar to previous procedures and all leads were placed close to the target area but away from scarred myocardium and the LPN. Patients that received real-time image-guided LV lead implantation were paced closer to the target area compared to patients that did not receive real-time image-guidance (8 mm [IQR 0-22] vs 26 mm [IQR 17-46], p = 0.04), and displayed marked LV reverse remodeling at 6 months follow up with a mean LVESV change of -30 ± 10% and a mean LVEF improvement of 15 ± 5%. Real-time image-guided LV lead implantation is feasible and may prove useful for achieving the optimal LV lead position.

Indexed as

Cardiac Resynchronization TherapyCardiac Resynchronization Therapy DevicesMagnetic Resonance Imaging, CineMultidetector Computed TomographyAgedCardiomyopathiesEquipment DesignFeasibility StudiesFemaleHeart VentriclesHumansMagnetic Resonance Imaging, InterventionalMaleMiddle AgedMultimodal ImagingMyocardial IschemiaCardiac resynchronization therapyImage fusionImage-guided interventionsMultimodality imagingTargeted lead placement

Identifiers

PMID30847659
PMCPMC6598949

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.