Evidence map›Paper›PMID 30847614›Full record

ArticleParasitology research2019

Oral infection of mice and host cell invasion by Trypanosoma cruzi strains from Mexico.

Cecilia G Barbosa, César Gómez-Hernández, Karine Rezende-Oliveira, Marcos Vinicius Da Silva, João Paulo Ferreira Rodrigues, Monique G S Tiburcio, Thatiane Bragini Ferreira, Virmondes Rodrigues, Nobuko Yoshida, Luis E Ramirez

Abstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Oral Route Infection byPathogens (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Mediators of inflammation · 2019
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Cecilia G BarbosaUniversidade Federal do Triângulo Mineiro, Rua Getúlio Guaritá S/N, Bairro Abadia, Uberaba, Minas Gerais, 38025-180, Brazil.
César Gómez-HernándezUniversidade Federal do Triângulo Mineiro, Rua Getúlio Guaritá S/N, Bairro Abadia, Uberaba, Minas Gerais, 38025-180, Brazil. cesar_cgh@hotmail.com.
Karine Rezende-OliveiraUniversidade Federal de Uberlândia, Ituiutaba, Minas Gerais, Brazil.
Marcos Vinicius Da SilvaUniversidade Federal do Triângulo Mineiro, Rua Getúlio Guaritá S/N, Bairro Abadia, Uberaba, Minas Gerais, 38025-180, Brazil.
João Paulo Ferreira RodriguesUniversidade Federal de São Paulo, São Paulo, Brazil.
Monique G S TiburcioUniversidade Federal do Triângulo Mineiro, Rua Getúlio Guaritá S/N, Bairro Abadia, Uberaba, Minas Gerais, 38025-180, Brazil.
Thatiane Bragini FerreiraUniversidade Federal do Triângulo Mineiro, Rua Getúlio Guaritá S/N, Bairro Abadia, Uberaba, Minas Gerais, 38025-180, Brazil.
Virmondes RodriguesUniversidade Federal do Triângulo Mineiro, Rua Getúlio Guaritá S/N, Bairro Abadia, Uberaba, Minas Gerais, 38025-180, Brazil.
Nobuko YoshidaUniversidade Federal de São Paulo, São Paulo, Brazil.
Luis E RamirezUniversidade Federal do Triângulo Mineiro, Rua Getúlio Guaritá S/N, Bairro Abadia, Uberaba, Minas Gerais, 38025-180, Brazil.
Universidade Federal do Triângulo Mineiro · BRUniversidade Federal de São Paulo · BRUniversidade Federal de Uberlândia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral infection by Trypanosoma cruzi has been responsible for frequent outbreaks of acute Chagas disease in the north of South America and in the Amazon region, where T. cruzi genetic group TcI predominates. TcI strains from different geographical regions have been used in oral infection in mice, but there is no information about strains from Mexico where TcI is prevalent. Here, we analyzed four Mexican strains as concerns the course of oral infection, the ability to invade host cells in vitro, and the profile of metacyclic trypomastigote surface molecules gp82 and gp90 that are implicated in parasite internalization. Oral infection of mice with metacyclic forms of all strains resulted in reduced blood and tissue parasitism, and mild to moderate inflammatory process in the heart/skeletal muscle. They expressed pepsin-resistant gp82 and gp90 molecules at high levels and invaded host cells poorly in full nutrient medium and efficiently under nutrient-deprived condition. The properties exhibited by Mexican strains were similar to those displayed by TcI strains from other geographical regions, reinforcing the notion that these features are common to the genetic group TcI as a whole.

Indexed as

AnimalsCell Line, TumorChagas DiseaseHeLa CellsHumansMexicoMiceProtozoan ProteinsSouth AmericaTrypanosoma cruziVariant Surface Glycoproteins, Trypanosomaglycoprotein GP82, Trypanosoma cruziglycoprotein GP90, Trypanosoma cruziProtozoan ProteinsVariant Surface Glycoproteins, TrypanosomaGenetic group TcIMetacyclic trypomastigoteMexican strainsOral infectionSurface molecules gp82 and gp90Trypanosoma cruzi

Identifiers

PMID30847614
OpenAlexW2922127548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.