ArticleGenome biology and evolution2019
A High-Quality Grapevine Downy Mildew Genome Assembly Reveals Rapidly Evolving and Lineage-Specific Putative Host Adaptation Genes.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Multivirulent Plasmopara viticola strains from Cilaos on Réunion Island break down Rpv1, Rpv3.1 and Rpv10 mediated resistance of grapevine.BMC plant biology · 2026Article
- Targeting and activation of BraATG8i by an RXLR effector DM459 contribute to downy mildew resistance inHorticulture research · 2026Article
- Parallel adaptation and admixture drive the evolution of virulence in the grapevine downy mildew pathogen.PLoS pathogens · 2026Article
- Phylogenomics of Plasmopara halstedii Reveals Genomic Regions Associated With the Breakdown of Sunflower Downy Mildew Resistance Genes.Molecular ecology · 2026Article
- Genome and transcriptome analyses reveal molecular mechanisms underlying the interaction betweenFrontiers in plant science · 2026Article
- Advances in grape and pathogen genomics toward durable grapevine disease resistance.Journal of experimental botany · 2025Review
- Review of the Pathogenic Mechanism of Grape Downy Mildew (Microorganisms · 2025Review
- A core Plasmopara viticola effector attenuates the DNA-binding activity of bZIP transcription factor to compromise plant immunity.The Plant journal : for cell and molecular biology · 2025Article
- Recombination landscape and karyotypic variations revealed by linkage mapping in the grapevine downy mildew pathogen Plasmopara viticola.G3 (Bethesda, Md.) · 2025Article
- Advances in the molecular mechanism of grapevine resistance to fungal diseases.Molecular horticulture · 2025Review
- The pathogenicity of Plasmopara viticola: a review of evolutionary dynamics, infection strategies and effector molecules.BMC plant biology · 2024Review
- Genomic and transcriptomic analyses ofFrontiers in microbiology · 2024Article
- A comparison of transporter gene expression in three species of Peronospora plant pathogens during host infection.PloS one · 2023Article
- A Comprehensive Assessment of the Secretome Responsible for Host Adaptation of the Legume Root PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- Review
- Article
- "Core" RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?Virulence · 2021Article
- Identification and Characterization of Downy Mildew-Responsive microRNAs in IndianJournal of fungi (Basel, Switzerland) · 2021Article
- Chloroplast genomes of five Oedogonium species: genome structure, phylogenetic analysis and adaptive evolution.BMC genomics · 2021Article
- The hop downy mildew pathogen Pseudoperonospora humuli.Molecular plant pathology · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Downy mildews are obligate biotrophic oomycete pathogens that cause devastating plant diseases on economically important crops. Plasmopara viticola is the causal agent of grapevine downy mildew, a major disease in vineyards worldwide. We sequenced the genome of Pl. viticola with PacBio long reads and obtained a new 92.94 Mb assembly with high contiguity (359 scaffolds for a N50 of 706.5 kb) due to a better resolution of repeat regions. This assembly presented a high level of gene completeness, recovering 1,592 genes encoding secreted proteins involved in plant-pathogen interactions. Plasmopara viticola had a two-speed genome architecture, with secreted protein-encoding genes preferentially located in gene-sparse, repeat-rich regions and evolving rapidly, as indicated by pairwise dN/dS values. We also used short reads to assemble the genome of Plasmopara muralis, a closely related species infecting grape ivy (Parthenocissus tricuspidata). The lineage-specific proteins identified by comparative genomics analysis included a large proportion of RxLR cytoplasmic effectors and, more generally, genes with high dN/dS values. We identified 270 candidate genes under positive selection, including several genes encoding transporters and components of the RNA machinery potentially involved in host specialization. Finally, the Pl. viticola genome assembly generated here will allow the development of robust population genomics approaches for investigating the mechanisms involved in adaptation to biotic and abiotic selective pressures in this species.
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