ArticleGenome biology and evolution2019
Genetic Variation in Pan Species Is Shaped by Demographic History and Harbors Lineage-Specific Functions.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- The SynMall resource for characterizing the functional impact of synonymous variation.Genome research · 2026Article
- Targeted Chromosomal Sequencing of Wild Bonobos Identifies a Genetically Distinct Subpopulation East of the Lomami River.bioRxiv : the preprint server for biology · 2026Article
- A curated dataset of great ape genome diversity.Scientific data · 2025Article
- High Gene Expression Predicts Extremely Low Segregation of Deleterious Mutations in Large Penguin Populations.Molecular biology and evolution · 2025Article
- Local genetic adaptation to habitat in wild chimpanzees.Science (New York, N.Y.) · 2025Article
- Local genetic adaptation to habitat in wild chimpanzees.bioRxiv : the preprint server for biology · 2024Article
- Sequence-based machine learning reveals 3D genome differences between bonobos and chimpanzees.bioRxiv : the preprint server for biology · 2023Article
- Regional TMPRSS2 V197M Allele Frequencies Are Correlated with COVID-19 Case Fatality Rates.Molecules and cells · 2021Article
- Current Progress in Evolutionary Comparative Genomics of Great Apes.Frontiers in genetics · 2021Review
- BetaScan2: Standardized Statistics to Detect Balancing Selection Utilizing Substitution Data.Genome biology and evolution · 2020Article
- Article
- The impact of genetic adaptation on chimpanzee subspecies differentiation.PLoS genetics · 2019Article
- Comparison of the Full Distribution of Fitness Effects of New Amino Acid Mutations Across Great Apes.Genetics · 2019Article
- A catalog of single nucleotide changes distinguishing modern humans from archaic hominins.Scientific reports · 2019Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) are the closest living relatives of humans, but the two species show distinct behavioral and physiological differences, particularly regarding female reproduction. Despite their recent rapid decline, the demographic histories of the two species have been different during the past 1-2 Myr, likely having an impact on their genomic diversity. Here, we analyze the inferred functional consequences of genetic variation across 69 individuals, making use of the most complete data set of genomes in the Pan clade to date. We test to which extent the demographic history influences the efficacy of purifying selection in these species. We find that small historical effective population sizes (Ne) correlate not only with low levels of genetic diversity but also with a larger number of deleterious alleles in homozygosity and an increased proportion of deleterious changes at low frequencies. To investigate the putative genetic basis for phenotypic differences between chimpanzees and bonobos, we exploit the catalog of putatively deleterious protein-coding changes in each lineage. We show that bonobo-specific nonsynonymous changes are enriched in genes related to age at menarche in humans, suggesting that the prominent physiological differences in the female reproductive system between chimpanzees and bonobos might be explained, in part, by putatively adaptive changes on the bonobo lineage.
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