Evidence map›Paper›PMID 30847420›Full record

ArticleJACC. Basic to translational science2019

Bioactive Materials Facilitating Targeted Local Modulation of Inflammation.

Richard P Tan, Alex H P Chan, Simon Wei, Miguel Santos, Bob S L Lee, Elysse C Filipe, Behnam Akhavan, Marcela M Bilek, Martin K C Ng, Yin Xiao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 56 citations in OpenAlex.

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  14. Monocyte Recruitment for Vascular Tissue Regeneration.Advanced healthcare materials · 2022
    Article
  15. Article
  16. Cell-Inspired Biomaterials for Modulating Inflammation.Tissue engineering. Part B, Reviews · 2022
    Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Richard P TanHeart Research Institute, Sydney, New South Wales, Australia.
Alex H P ChanHeart Research Institute, Sydney, New South Wales, Australia.
Simon WeiScience and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.
Miguel SantosHeart Research Institute, Sydney, New South Wales, Australia.
Bob S L LeeHeart Research Institute, Sydney, New South Wales, Australia.
Elysse C FilipeSydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Behnam AkhavanHeart Research Institute, Sydney, New South Wales, Australia.
Marcela M BilekSchool of Physics, University of Sydney, Sydney, New South Wales, Australia.
Martin K C NgSydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Yin XiaoScience and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.
Steven G WiseHeart Research Institute, Sydney, New South Wales, Australia.
The Heart Research Institute · AUUniversity of Sydney · AUQueensland University of Technology · AURoyal Prince Alfred Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease is an inflammatory disorder that may benefit from appropriate modulation of inflammation. Systemic treatments lower cardiac events but have serious adverse effects. Localized modulation of inflammation in current standard treatments such as bypass grafting may more effectively treat CAD. The present study investigated a bioactive vascular graft coated with the macrophage polarizing cytokine interleukin-4. These grafts repolarize macrophages to anti-inflammatory phenotypes, leading to modulation of the pro-inflammatory microenvironment and ultimately to a reduction of foreign body encapsulation and inhibition of neointimal hyperplasia development. These resulting functional improvements have significant implications for the next generation of synthetic vascular grafts.

Indexed as

CAD, coronary artery diseasecovalent biomolecule immobilizationELISA, enzyme-linked immunoadsorbent assayIL, interleukininflammationinterleukin-4neointimal hyperplasiaPCL, polycaprolactonePIII, plasma immersion ion implantationplasma-based ion implantationqPCR, quantitative polymerase chain reactionradical functionalized surfaceTGF, transforming growth factorTNF, tumor necrosis factorvascular graft

Identifiers

PMID30847420
PMCPMC6390730
OpenAlexW2916642185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.