ArticleJACC. Basic to translational science2019
Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis.
Open access · goldAbstract read
In one paragraph
Article in JACC. Basic to translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- The role of CD36 in immune function: bridging innate and adaptive responses.Frontiers in immunology · 2026Pooled it
- National Psoriasis Foundation COVID-19 Task Force Guidance for Management of Psoriatic Disease During the Pandemic: Version 1.Journal of the American Academy of Dermatology · 2020Guideline
- Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1.Arteriosclerosis, thrombosis, and vascular biology · 2020Trial
- Low-density neutrophil heterogeneity and spleen tyrosine kinase as therapeutic targets in sepsis.JCI insight · 2026Article
- The role of neutrophils in the pathogenesis of abdominal aortic aneurysms.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Trajectory-based profiling of 52-week secukinumab response reveals baseline clinical and transcriptomic differences in plaque psoriasis.Frontiers in immunology · 2026Article
- From skin to heart: a state-of-the-art perspective on psoriasis-driven cardiovascular comorbidities.Frontiers in immunology · 2026Review
- Cardiovascular Disease and Psoriasis.Dermatology and therapy · 2026Review
- Biological roles and clinical translation of low-density neutrophils in rheumatic, autoimmune and inflammatory diseases: paradigm reconstruction and unresolved questions.Frontiers in immunology · 2026Review
- Advances in the study of low-density neutrophils in rheumatic diseases.Frontiers in immunology · 2026Review
- Elevated Spleen Tyrosine Kinase in Low-Density Neutrophils During Bacterial Sepsis in a Nonhuman Primate Model.The Journal of infectious diseases · 2025Article
- Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases.Trends in immunology · 2025Review
- Cardiovascular disease risk in psoriatic disease: mechanisms and implications for clinical practice.Current opinion in rheumatology · 2025Review
- Cardiodermatology: the heart of the connection between the skin and cardiovascular disease.Nature reviews. Cardiology · 2025Review
- Statin Use in Special Populations for the Prevention of Cardiovascular Disease in Adults.Current atherosclerosis reports · 2025Review
- Interaction of low-density neutrophils with other immune cells in the mechanism of inflammation.Molecular medicine (Cambridge, Mass.) · 2025Review
- Association of systemic immune-inflammation index (SII) with risk of psoriasis: a cross-sectional analysis of National Health and Nutrition Examination Survey 2011-2014.European journal of medical research · 2025Article
- Association of the Monocyte-to-High Density Lipoprotein Ratio with the FRS and as a Predictor of Cardiovascular Risk in Individuals with Psoriasis Vulgaris.Clinical, cosmetic and investigational dermatology · 2025Article
- Low-Density Neutrophils: Enigmatic Cells in Health and Disease.Journal of immunology research · 2025Review
- Circulating Oxidized mtDNA is Associated Broadly with Cardiovascular Disease in a Longitudinal Cohort Study of Psoriasis.JID innovations : skin science from molecules to population health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 6 institutions in 1 country.
Heather L TeagueNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Nevin J VargheseNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Lam C TsoiDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan.
Amit K DeyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Michael S GarshickDepartment of Medicine, Division of Cardiology, New York University School of Medicine, New York, New York.
Joanna I SilvermanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Yvonne BaumerNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Charlotte L HarringtonNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Erin StempinskiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Youssef A ElnabawiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Pradeep K DagurNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Kairong CuiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Ilker TuncNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Fayaz SeifuddinNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Aditya A JoshiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Elena StanskyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Monica M PurmalekSystemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Justin A RodanteNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Andrew KeelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Tarek Z AridiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Carmelo Carmona-RiveraSystemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Gregory E SandaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Marcus Y ChenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Mehdi PiroozniaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
J Philip McCoyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Joel M GelfandDepartment of Dermatology, Perelman School of Medicine, Philadelphia, Pennsylvania.
Keji ZhaoNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan.
Martin P PlayfordNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Mariana J KaplanSystemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Jeffrey S BergerDepartment of Medicine, Division of Cardiology, New York University School of Medicine, New York, New York.
Nehal N MehtaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
National Institutes of Health · USNational Heart Lung and Blood Institute · USNew York University · USMichigan Medicine · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · US
Funding
Systemic AutoimmunityZIAAR041199 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KAPLAN, MARIANA · 2014 to 2025
$32.5MFlow Cytometry Core FacilityZICHL005905 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DAGUR, PRADEEP · 2009 to 2025
$32.3MCardiovascular CT Clinical ResearchZIAHL006220 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHEN, MARCUS · 2017 to 2025
$22.5MEpigenetic Regulation of Hematopoietic Stem CellsZIAHL006031 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZHAO, KEJI · 2009 to 2025
$16.6MUniversity of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6MBioinformatics CoreZICHL006228 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI PIROOZNIA, MEHDI · 2017 to 2021
$6.6MTRAINING OF ARTHRITIS RESEARCH SCIENTISTST32AR007080 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Knight · 1986 to 2026
$6.3MRole of IL-13 and the IL-13 Associated rs20541 Risk Variant in the Pathogenesis of PsoriasisR01AR069071 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2015 to 2019
$2.1MNIAMS NIH HHS P30 AR075043NIAMS NIH HHS R01 AR069071NIAMS NIH HHS T32 AR007080
Abstract
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte-platelet interaction may play a crucial target for clinical intervention.
Indexed as
cardiovascular diseaseCCTA, coronary computed tomography angiographyCVD, cardiovascular diseaseFDR, false discovery rateHAoEC, human aortic endothelial cellLDG, low-density granulocytelow-density granulocytesMI, myocardial infarctionNCB, noncalcified coronary plaque burdenNDG, normal-density granulocyteNET, neutrophil extracellular trapneutrophilsPASI, psoriasis area severity indexplateletspsoriasisSLE, systemic lupus erythematosusTB, total coronary plaque burden
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.