Evidence map›Paper›PMID 30847408›Full record

ArticleParasite epidemiology and control2019

Immunological evaluation of fusion protein of

Rajkumar Paul, Meganathan Ilamaran, Vishal Khatri, Nitin Amdare, Maryada Venkata Rami Reddy, Perumal Kaliraj

Open access · goldAbstract read
In one paragraph

Article in Parasite epidemiology and control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Dose-Dependent Prophylactic Efficacy of Filarial Antigens Glutathione-S-Transferase and Abundant Larval Transcript-2 againstThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rajkumar PaulCentre for Biotechnology, Anna University, Sardar Patel Road, Guindy, Chennai 600025, Tamil Nadu, India.
Meganathan IlamaranCentre for Biotechnology, Anna University, Sardar Patel Road, Guindy, Chennai 600025, Tamil Nadu, India.
Vishal KhatriDepartment of Biochemistry & J.B. Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India.
Nitin AmdareDepartment of Biochemistry & J.B. Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India.
Maryada Venkata Rami ReddyDepartment of Biochemistry & J.B. Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India.
Perumal KalirajCentre for Biotechnology, Anna University, Sardar Patel Road, Guindy, Chennai 600025, Tamil Nadu, India.
Anna University, Chennai · INMahatma Gandhi Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFilariasis, a neglected tropical helminth disease needs vaccine besides mass drug administration for its successful eradication.

methodsAn attempt was made to produce a fusion protein (P-TUFT-ALT-2) of abundant larval transcript protein-2 and Tuftsin to enhance its immunogenicity. The fusion construct was expressed in RESULT AND DISCUSSION: P-TUFT-ALT-2 showed an enhanced IgG peak titre compared to

conclusionThis experiment validates P-TUFT-ALT-2 as a potential vaccine candidate for human lymphatic filariasis.

Indexed as

Abundant larval transcript-2Balb/c miceLymphatic filariasisPichia pastorisTuftsinVaccine candidate

Identifiers

PMID30847408
PMCPMC6378782
OpenAlexW2913975928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.