Evidence map›Paper›PMID 30847391›Full record

ArticleLaryngoscope investigative otolaryngology2019

The current practice of open neck mass biopsy in the diagnosis of head and neck cancer: A retrospective cohort study.

Sarah R Akkina, Roderick Y Kim, Chaz L Stucken, Melissa A Pynnonen, Carol R Bradford

Open access · goldAbstract read
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah R AkkinaDepartment of Otolaryngology-Head and Neck Surgery University of Washington Seattle Washington.ORCID https://orcid.org/0000-0002-0166-3901
Roderick Y Kimthe Section of Oral and Maxillofacial Surgery University of Michigan Health System Ann Arbor Michigan.
Chaz L StuckenDepartment of Surgery; and the Department of Otolaryngology-Head and Neck Surgery University of Michigan Health System Ann Arbor Michigan.
Melissa A PynnonenDepartment of Surgery; and the Department of Otolaryngology-Head and Neck Surgery University of Michigan Health System Ann Arbor Michigan.
Carol R BradfordDepartment of Surgery; and the Department of Otolaryngology-Head and Neck Surgery University of Michigan Health System Ann Arbor Michigan.
University of Michigan · USUniversity of Washington · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Therapeutic Potential and Mechanism of Action of Potent Small Molecule InhibitorsP50CA097248 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOLF, GREGORY T · 2002 to 2013
$25.3M
NCI NIH HHS P30 CA046592NCI NIH HHS P50 CA097248
6 · The paper itself

Abstract

objectiveTo characterize current use of open neck mass biopsy for diagnosis of squamous cell carcinoma in patients presenting with a neck mass.

methodsUsing the University of Michigan Specialized Program of Research Excellence in Head and Neck Cancer patient database (2008-2014), we reviewed patients' referral documentation to identify those who received open neck mass biopsies as part of their squamous cell carcinoma diagnosis. We compared subsequent treatment between patients who did and did not receive an open neck mass biopsy.

resultsOf 940 patients, 50 patients had received open neck mass biopsy leading to squamous cell carcinoma diagnosis. Only 19 of 50 patients (38%) had undergone fine-needle aspiration prior to open neck mass biopsy. There were no statistically significant differences in treatment or outcomes between patients who did and those who did not receive open neck mass biopsy.

conclusionOptimal care for patients who present with a neck mass is fine-needle aspiration. Unfortunately, these data show that many patients undergo open neck mass biopsy for diagnosis, often without prior fine-needle aspirate. Compared to fine-needle aspiration, open biopsy incurs additional risks of general anesthesia and greater surgical risks. While our data did not find statistically significant differences between treatment offered and outcomes, this small study was not expected to demonstrate a difference in outcomes. Further work is needed to promote the utility of fine-needle aspiration for diagnosis of neck mass and to discourage use of open neck mass biopsy as a primary diagnostic intervention. LEVEL OF EVIDENCE: 2c (Outcomes Research).

Indexed as

Head and neck squamous cell cancermetastatic lymph nodeopen neck mass biopsy

Identifiers

PMID30847391
PMCPMC6383295
OpenAlexW2909977976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.