Evidence map›Paper›PMID 30847389›Full record

ArticleeNeuro

A Poly-Glutamine Region in the

Samuel W Vernon, Jim Goodchild, Richard A Baines

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Vesicular neurotransmitter transporters in Drosophila melanogaster.Biochimica et biophysica acta. Biomembranes · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Samuel W VernonDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, United Kingdom.
Jim GoodchildSyngenta Ltd, Bracknell, Berkshire RG42 6EY, United Kingdom.
Richard A BainesDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, United Kingdom.ORCID 0000-0001-8571-4376
Manchester Academic Health Science Centre · GBSyngenta (United Kingdom) · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L027690/1Wellcome Trust 087742/Z/08/Z
6 · The paper itself

Abstract

While the primary role of vesicular transporters is to load neurotransmitters into synaptic vesicles (SVs), accumulating evidence suggests that these proteins also contribute to additional aspects of synaptic function, including vesicle release. In this study, we extend the role of the VAChT to include regulating the transmitter content of SVs. We report that manipulation of a C-terminal poly-glutamine (polyQ) region in the

Indexed as

AcetylcholineAnimalsAnimals, Genetically ModifiedDrosophilaDrosophila ProteinsExcitatory Postsynaptic PotentialsMiniature Postsynaptic PotentialsMotor NeuronsOptogeneticsPatch-Clamp TechniquesSynaptic VesiclesVesicular Acetylcholine Transport ProteinsAcetylcholineDrosophila ProteinsVAChT protein, DrosophilaVesicular Acetylcholine Transport ProteinsacetylcholineDrosophilaneurotransmittersynapsesynaptic vesicletransporter

Identifiers

PMID30847389
PMCPMC6402538
OpenAlexW2953474660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.