Evidence map›Paper›PMID 30847353›Full record

ArticleJournal of immunology research2019

Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer.

Juan José Mora Román, Miguel Del Campo, Javiera Villar, Francesca Paolini, Gianfranca Curzio, Aldo Venuti, Lilian Jara, Jorge Ferreira, Paola Murgas, Alvaro Lladser and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Modified Hemocyanins fromMarine drugs · 2024
    Article
  5. Article
  6. Review
  7. Assessment of theBiomedicines · 2023
    Article
  8. Review
  9. Review
  10. Insights into Common Octopus (Marine drugs · 2023
    Article
  11. Antitumor Activity of Bioactive Compounds fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Review
  14. Hybrid Nanoparticles of Proanthocyanidins fromPlants (Basel, Switzerland) · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Hemocyanins fromBiomedicines · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Juan José Mora RománFundación Ciencia y Tecnología para el Desarrollo (FUCITED), Avenida Alcalde Eduardo Castillo Velasco 2902, Santiago, Chile.
Miguel Del CampoFundación Ciencia y Tecnología para el Desarrollo (FUCITED), Avenida Alcalde Eduardo Castillo Velasco 2902, Santiago, Chile.
Javiera VillarFundación Ciencia y Tecnología para el Desarrollo (FUCITED), Avenida Alcalde Eduardo Castillo Velasco 2902, Santiago, Chile.
Francesca PaoliniHPV-Unit-UOSD Tumor Immunology and Immunotherapy, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.
Gianfranca CurzioHPV-Unit-UOSD Tumor Immunology and Immunotherapy, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.
Aldo VenutiHPV-Unit-UOSD Tumor Immunology and Immunotherapy, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.ORCID 0000-0003-2322-6857
Lilian JaraHuman Genetics Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile.
Jorge FerreiraClinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile.
Paola MurgasLaboratory of Immunoncology, Fundación Ciencia & Vida, Av. Zañartu 1482, Santiago, Chile.
Alvaro LladserLaboratory of Immunoncology, Fundación Ciencia & Vida, Av. Zañartu 1482, Santiago, Chile.
Augusto ManubensBIOSONDA Corporation, Avenida Alcalde Eduardo Castillo Velasco 2902, Santiago, Chile.
María Inés BeckerFundación Ciencia y Tecnología para el Desarrollo (FUCITED), Avenida Alcalde Eduardo Castillo Velasco 2902, Santiago, Chile.ORCID 0000-0002-9711-2222
Fundación Chile · CLIstituti di Ricovero e Cura a Carattere Scientifico · ITFundación Ciencia and Vida · CLUniversity of Chile · CLProduction Development Corporation · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as carriers/adjuvants of tumor-associated antigens in cancer vaccine development and as adjuvants to dendritic cell-based immunotherapy, because these glycoproteins induce a bias towards Th1 immunity. Here, we analyzed the preclinical therapeutic potential of the traditional keyhole limpet hemocyanin (KLH) and two new hemocyanins from

Indexed as

ImmunotherapyAdjuvants, ImmunologicAlum CompoundsAnimalsCarcinoma, Squamous CellCell Line, TumorDisease Models, AnimalFemaleHemocyaninsImmunity, CellularImmunity, HumoralMiceMice, Inbred C57BLMolluscaMouth NeoplasmsPolysorbatesAddavaxAdjuvants, ImmunologicAlum Compoundsaluminum sulfateHemocyaninskeyhole-limpet hemocyaninPolysorbatessaponin QA-21V1SaponinsSqualene

Identifiers

PMID30847353
PMCPMC6362480
OpenAlexW2908802491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.