ReviewFrontiers in veterinary science2019
Nutritional Intervention for the Intestinal Development and Health of Weaned Pigs.
Review in Frontiers in veterinary science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
119 citing papers in PubMed, 188 citations in OpenAlex.
- Graded levels of wheat oligopeptides relieve feed change-induced intestinal damage via modulation of the Wnt/β-catenin signaling pathway in broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Growth Performance and Antioxidant Responses to Dietary Flavonoids in Swine: A Systematic Review and Meta-Analysis with Exploratory Dose-Time Relationships.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- Correlation between the barrier function of the intestinal epithelium and susceptibility to PEDV infection in piglets at different ages.Veterinary research · 2026Article
- Influence of Enzymatically Hydrolyzed Whole Blood Formulated Diet on Nutrient Digestibility, Fecal Bacterial Count, and Immune Responses of Weaned Piglets Challenged withLife (Basel, Switzerland) · 2026Article
- The role of gut permeability in livestock: methods to study the effects of stress on gut permeability and energy consumption.Animal frontiers : the review magazine of animal agriculture · 2026Article
- Gut microbiota: A key player for soluble dietary fiber in regulating inflammatory disease.Journal of advanced research · 2026Review
- Recent Advances in Natural Products for Colitis: Mechanisms and Translational Perspectives.Veterinary sciences · 2026Review
- Current Trends, Future Prospects and Constraints of Whole Microalgae and Their Fractions as a Functional Feed Ingredient for Animals.Journal of animal physiology and animal nutrition · 2026Review
- Feeding of Undocked Pigs: Effects of Feed Components and Feed Composition.Animals : an open access journal from MDPI · 2026Review
- Exploratory identification of intestinal health and productive performance patterns in post-weaning piglets using explainable machine learning.Veterinary research communications · 2026Article
- Integrated Transcriptomics and Targeted Metabolomics Approaches: Comparative Analysis of the Ileum in Neonatal Piglets with Different Birth Weight.Animals : an open access journal from MDPI · 2026Article
- Porcine gut loops to explore the impact of amino acids on the host-microbiota crosstalk in the ileum.Frontiers in microbiology · 2026Article
- Effect of nursery phase feeding budgets on growth performance and economics in weanling pigs.Translational animal science · 2026Article
- Bone Growth and Development in Different Breeds of Piglets at the Early Age Is Associated with Mineral Deposition.Animals : an open access journal from MDPI · 2025Article
- UPGG: expanding the taxonomic and functional diversity of the pig gut microbiome with an enhanced genome catalog.NPJ biofilms and microbiomes · 2025Article
- Effects of paraformic acid supplementation, as an antibiotic replacement, on growth performance, intestinal morphology and gut microbiota of nursery pigs.Journal of animal science and technology · 2025Article
- Protease Enzyme Supplementation in Weaning Piglets Fed Reduced Crude Protein Diets: Effects on Gut Health Integrity and Performance Response.Animals : an open access journal from MDPI · 2025Article
- Integrated Transcriptome and Metabolome Analysis of the Porcine Small Intestine During Weaning.Genes · 2025Article
- Supplementation with Potato Protein Concentrate andAnimals : an open access journal from MDPI · 2025Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weaning imposes simultaneous stress, resulting in reduced feed intake, and growth rate, and increased morbidity and mortality of weaned pigs. Weaning impairs the intestinal integrity, disturbs digestive and absorptive capacity, and increases the intestinal oxidative stress, and susceptibility of diseases in piglets. The improvement of intestinal development and health is critically important for enhancing nutrient digestibility capacity and disease resistance of weaned pigs, therefore, increasing their survival rate at this most vulnerable stage, and overall productive performance during later stages. A healthy gut may include but not limited several important features: a healthy proliferation of intestinal epithelial cells, an integrated gut barrier function, a preferable or balanced gut microbiota, and a well-developed intestinal mucosa immunity. Burgeoning evidence suggested nutritional intervention are one of promising measures to enhance intestinal health of weaned pigs, although the exact protective mechanisms may vary and are still not completely understood. Previous research indicated that functional amino acids, such as arginine, cysteine, glutamine, or glutamate, may enhance intestinal mucosa immunity (i.e., increased sIgA secretion), reduce oxidative damage, stimulate proliferation of enterocytes, and enhance gut barrier function (i.e., enhanced expression of tight junction protein) of weaned pigs. A number of feed additives are marketed to assist in boosting intestinal immunity and regulating gut microbiota, therefore, reducing the negative impacts of weaning, and other environmental challenges on piglets. The promising results have been demonstrated in antimicrobial peptides, clays, direct-fed microbials, micro-minerals, milk components, oligosaccharides, organic acids, phytochemicals, and many other feed additives. This review summarizes our current understanding of nutritional intervention on intestinal health and development of weaned pigs and the importance of mechanistic studies focusing on this research area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.