Evidence map›Paper›PMID 30847303›Full record

ArticleFrontiers in oncology2019

Putative Role of Circulating Human Papillomavirus DNA in the Development of Primary Squamous Cell Carcinoma of the Middle Rectum: A Case Report.

Maria Raffaella Ambrosio, Remo Vernillo, Sabrina De Carolis, Antonietta Carducci, Lucia Mundo, Alessandro Ginori, Bruno Jim Rocca, Valerio Nardone, Alessandra Lucenti Fei, Tommaso Carfagno and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Role of extracellular vesicle in human papillomavirus-associated cervical cancer.Journal of cancer research and clinical oncology · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Extracellular Vesicles in Viral Infections: Two Sides of the Same Coin?Frontiers in cellular and infection microbiology · 2020
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Maria Raffaella AmbrosioDepartment of Medical Biotechnology, University of Siena, Siena, Italy.
Remo VernilloDepartment of Medical Sciences, Surgery and Neuroscience, University of Siena, Siena, Italy.
Sabrina De CarolisCenter of Applied Biomedical Research (CRBA), S. Orsola-Malpighi Hospital, Bologna, Italy.
Antonietta CarducciDepartment of Medical Biotechnology, University of Siena, Siena, Italy.
Lucia MundoDepartment of Medical Biotechnology, University of Siena, Siena, Italy.
Alessandro GinoriPathology Unit, Ospedale Civico di Carrara, Carrara, Italy.
Bruno Jim RoccaPathology Unit, Ospedale Civico di Carrara, Carrara, Italy.
Valerio NardoneRetired, Siena, Italy.
Alessandra Lucenti FeiDepartment of Medical Sciences, Surgery and Neuroscience, University of Siena, Siena, Italy.
Tommaso CarfagnoRetired, Siena, Italy.
Stefano LazziDepartment of Medical Biotechnology, University of Siena, Siena, Italy.
Monica CriccaDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Piero TosiRetired, Siena, Italy.
University of Siena · ITAccademia di Belle Arti di Carrara · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we present the case of a patient affected by rectal squamous cell carcinoma in which we demonstrated the presence of Human Papillomavirus (HPV) by a variety of techniques. Collectively, the virus was detected not only in the tumor but also in some regional lymph nodes and in non-neoplastic mucosa of the upper tract of large bowel. By contrast, it was not identifiable in its common sites of entry, namely oral and ano-genital region. We also found HPV DNA in the plasma-derived exosome. Next, by

Indexed as

cancercirculating HPVexosomesimmune evasionmiddle rectum

Identifiers

PMID30847303
PMCPMC6394246
OpenAlexW2915107373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.