Evidence map›Paper›PMID 30847194›Full record

ArticleClinical case reports2019

A child with Klinefelter syndrome and both IgE-mediated food allergy and low proportion of naive Treg.

Rachel Frederick, Peter Vuillermin, Mimi L K Tang, Anne-Louise Ponsonby, Elise Webster, Richard Saffery, Fiona Collier, Barwon Infant Study Investigator Group

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rachel FrederickChild Health Research Unit Barwon Health Geelong Victoria Australia.
Peter VuillerminChild Health Research Unit Barwon Health Geelong Victoria Australia.
Mimi L K TangSchool of Medicine Deakin University Geelong Victoria Australia.
Anne-Louise PonsonbySchool of Medicine Deakin University Geelong Victoria Australia.
Elise WebsterChild Health Research Unit Barwon Health Geelong Victoria Australia.
Richard SafferySchool of Medicine Deakin University Geelong Victoria Australia.
Fiona CollierChild Health Research Unit Barwon Health Geelong Victoria Australia.ORCID 0000-0002-5438-480X
Barwon Infant Study Investigator Group
Barwon Health · AUDeakin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case suggests a possible association between Klinefelter Syndrome and decreased regulatory T cells (Treg) cells, relating to an increased risk of allergic and autoimmune disorders in these patients. The immune phenotyping of the circulating FOXP3+ naive Treg populations in KS patients may help to indicate this predisposition.

Indexed as

FoxP3Klinefelter syndromeregulatory T cell

Identifiers

PMID30847194
PMCPMC6389460
OpenAlexW2908687731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.