ArticleMolecular and clinical oncology2019
Expression of keratin 15 in dentigerous cyst, odontogenic keratocyst and ameloblastoma.
Article in Molecular and clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- SOX2 and cytokeratins 5, 8 and 18 as potential stem cell biomarkers in botryoid odontogenic, lateral periodontal and gingival cysts.Histology and histopathology · 2026Article
- Construction and evaluation of a prognostic model for breast cancer based on aging related genes.Scientific reports · 2025Article
- The Expression of HIF-1α and VEGF in Radicular Cysts and Periapical Granulomas.European journal of dentistry · 2025Article
- Keratin-15 high expression links with lymph node metastasis and poor survival prognosis in epithelial ovarian cancer patients.Discover oncology · 2024Article
- The correlated expression of COX-2 and keratin 15 in radicular cysts.Journal of clinical and experimental dentistry · 2022Article
- Amelogenin in calcified matrices of odontogenic cysts and odontogenic tumors: An immunohistochemical study.Journal of dental sciences · 2021Article
- Activation of mesenchymal stem cells promotes new bone formation within dentigerous cyst.Stem cell research & therapy · 2020Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology and pathogenesis of odontogenic lesions are poorly understood. Keratin 15 (K15) is a type I cytoskeletal protein that provides structural support to the cells and has been considered to be a stem cell marker. The aim of the present study was to evaluate the expression of K15 in the epithelial lining of dentigerous cysts (DCs), odontogenic keratocysts (OKCs) and ameloblastomas (ABs). The study included 41 samples of DCs (n=13), OKCs (n=12), and AB tissues (n=16). K15 protein expression was evaluated via immunohistochemistry and data were statistically analyzed using a Kruskal-Wallis test. K15 was expressed in the majority of the studied lesions with various distributions in the different study samples. The Kruskal-Wallis test revealed non-significant differences in the expression of K15 among the three odontogenic lesions (P=0.380). The present study confirmed the high expression of K15 in the different epithelial layers of DC, OKC and AB. This type of expression excludes the reliability of regarding K15 as a stem cell marker in DC, OKC and AB. However, K15 may reflect the abnormal differentiation of pathological epithelial cells in these lesions.
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