ArticleOncotarget2019
Immune response characterization of endometrial cancer.
Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Advances in Immunotherapy for Endometrial Cancer: Insights into MMR Status and Tumor Microenvironment.Cancers · 2024Review
- Investigation ofTurkish journal of obstetrics and gynecology · 2024Article
- IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer.Cancer research · 2022Article
- Construction of a microenvironment immune gene model for predicting the prognosis of endometrial cancer.BMC cancer · 2021Article
- Bioinformatic profiling identifies prognosis-related genes in the immune microenvironment of endometrial carcinoma.Scientific reports · 2021Article
- Development and validation of nomogram with tumor microenvironment-related genes and clinical factors for predicting overall survival of endometrial cancer.Journal of Cancer · 2021Article
- Endometrial Tumour Microenvironment.Advances in experimental medicine and biology · 2020Article
- First description of ultramutated endometrial cancer caused by germline loss-of-function and somatic exonuclease domain mutations in POLE gene.Genetics and molecular biology · 2020Article
- Prognostic Implications of Immune-Related Genes' (IRGs) Signature Models in Cervical Cancer and Endometrial Cancer.Frontiers in genetics · 2020Article
- Survival correlation of immune response in human cancers.Oncotarget · 2019Article
- Clinicopathological correlation of immune response in human cancers.Oncotarget · 2019Article
- A global immune gene expression signature for human cancers.Oncotarget · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
backgroundThe comprehensive characterization and prognostic relevance of immune activation in endometrial cancer remain largely unknown.
resultsWe systematically reported a subset of endometrioid-type endometrial cancer characterized by multifaceted immune features such as low tumor purity, high leukocyte percentage, and striking
methodsWe obtained the multi-dimensional genomic data from publicly available databases and correlated them with the four gene expression-based subtypes we recently identified in endometrial cancer. Upstream regulator analysis was used to identify the most significantly enriched transcription regulators and Ingenuity pathway analysis was applied to determine enrichment of signaling pathways in survival-associated genes. Gene set enrichment analysis was performed on the 200-gene T-cell tumor infiltration gene signature comparing Cluster IV with the other three clusters combined. All statistical tests were two-sided, and a
conclusionThis study helps to identify patients with immune activation who are likely to benefit from emerging immune checkpoint inhibitors.
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