Evidence map›Paper›PMID 30847022›Full record

ArticleOncotarget2019

Recurrent hotspot SF3B1 mutations at codon 625 in vulvovaginal mucosal melanoma identified in a study of 27 Australian mucosal melanomas.

Camelia Quek, Robert V Rawson, Peter M Ferguson, Ping Shang, Ines Silva, Robyn P M Saw, Kerwin Shannon, John F Thompson, Nicholas K Hayward, Georgina V Long and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Distinct and convergent effects ofProceedings of the National Academy of Sciences of the United States of America · 2025
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  11. Article
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  16. Article
  17. Article
  18. Molecular Genetics of Conjunctival Melanoma and Prognostic Value ofInternational journal of molecular sciences · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Camelia QuekMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Robert V RawsonMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Peter M FergusonMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Ping ShangMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Ines SilvaMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Robyn P M SawMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Kerwin ShannonMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
John F ThompsonMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Nicholas K HaywardMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Georgina V LongMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Graham J MannMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Richard A ScolyerMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
James S WilmottMelanoma Institute Australia, The University of Sydney, Sydney, Australia.
Melanoma Institute Australia · AURoyal Prince Alfred Hospital · AUUniversity of Sydney · AURoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionClinical outcomes for mucosal melanomas are often poor due to a lack of effective systemic drug therapies. Identifying driver genes in mucosal melanoma may enhance the understanding of disease pathogenesis and provide novel opportunities to develop effective therapies.

resultsSomatic variant analysis identified

conclusionMolecular subgroups of mucosal melanoma with

methodsFormalin-fixed biopsies were collected from 27 pathologically-confirmed mucosal melanomas. Genomic DNA was isolated from the tumor tissue and sequenced using a novel dual-strand amplicon sequencing technique to determine the frequency and types of mutations across 45 target genes.

Indexed as

hotspot mutationmucosal melanomaSF3B1spliceosometargeted sequencing

Identifiers

PMID30847022
PMCPMC6398173
OpenAlexW2913100067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.