ArticleScientific reports2019
Daiokanzoto (Da-Huang-Gan-Cao-Tang) is an effective laxative in gut microbiota associated with constipation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Juzentaihoto modulates gut microbiota and potentiates the anti-tumor effect of anti-PD-1 antibody in an immunogenic mouse melanoma model.Journal of natural medicines · 2026Article
- Role of the gut microbiota in the pharmacological effects of traditional Kampo medicine and natural products.Journal of natural medicines · 2025Review
- Association between the dietary index for gut microbiota and constipation in American adults.Nutrition journal · 2025Article
- Laxative effect of Zengye granule by modulating the SCF/c-Kit pathway and gut microbiota in constipated mice.Frontiers in veterinary science · 2025Article
- Comparison of the conventional and immersing powdered crude drugs (IPCD) methods for color and extraction of quantitative indicator ingredients in the Kampo formula decoction of daiokanzoto.Journal of pharmaceutical health care and sciences · 2023Article
- Clinical Relevance of Gut Microbiota Alterations under the Influence of Selected Drugs-Updated Review.Biomedicines · 2023Review
- Recent Advances inMetabolites · 2022Review
- Transdermal Administration of Volatile Oil fromOxidative medicine and cellular longevity · 2022Article
- Role of gut microbiota in functional constipation.Gastroenterology report · 2021Review
- Anthraquinone-containing compound in rhubarb prevents indole production via functional changes in gut microbiota.Journal of natural medicines · 2021Article
- Gut microbiota is involved in the alleviation of loperamide-induced constipation by honey supplementation in mice.Food science & nutrition · 2020Article
- Gut Microbiota Composition Changes in Constipated Women of Reproductive Age.Frontiers in cellular and infection microbiology · 2020Article
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4 authors.
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Abstract
Interindividual differences affect the purgative activities of sennoside A (SA) and Daiokanzoto (Da-Huang-Gan-Cao-Tang, DKT). In this study, we manipulated gut microbiota in mice to establish laxative responders and non-responders by feeding them a high-carbohydrate, a high-fat or a high-fibre diet. To assess the relationship between laxatives and gut microbiota, we monitored the gut microbiota before and after administering laxatives. Twenty mice per diet were divided into four groups of five mice to evaluate purgative activities of four laxative preparations, DKT, SA, SA plus rhein 8-O-β-D-glucopyranoside (SA + RG), and SA plus liquiritin (SA + LQ). Gut microbiota changes were monitored by next-generation sequencing of 16 S rRNA gene amplicons. In high-carbohydrate and high-fat diet-fed mice, DKT exerted a significantly higher purgative activity than SA alone, and RG contributed to this activity. DKT and SA + RG administration increased the Enterobacteriaceae content of gut microbiota, which was associated with an increased purgative activity. In contrast, DKT activity was significantly suppressed by high-fibre diet. Hence, diet-induced differences in gut microbiota determined the effect of DKT, which is interesting, considering that Oriental medicines are formulated for a specific functional state or "pattern". These results demonstrated that the purgative activity of anthranoid laxatives is susceptible to diet-induced alterations in gut microbiota.
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