Evidence map›Paper›PMID 30846717›Full record

ArticleScientific reports2019

Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia.

Erika Lindberg, Helena Hammarström, Nasser Ataollahy, Nahid Kondori

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  9. Journal of clinical microbiology · 2024
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  12. The impact of increasing non-albicans Candida trends on diagnostics in immunocompromised patients.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  13. Paradigm Shift:Journal of fungi (Basel, Switzerland) · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Triazole Derivatives Target 14α-Demethylase (LDM) Enzyme inJournal of fungi (Basel, Switzerland) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Erika LindbergDepartment of Infectious Diseases, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Helena HammarströmDepartment of Infectious Diseases, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Nasser AtaollahyDepartment of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Nahid KondoriDepartment of Infectious Diseases, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. nahid.kondori@microbio.gu.se.
Sahlgrenska University Hospital · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candida albicans is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans Candida species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fungi isolated from the blood samples of patients at a Swedish University Hospital and to define the in vitro susceptibilities of these isolates to nine antifungal agents. In total, 233 yeast isolates from 143 patients were included in this study. Antifungal susceptibility testing was performed using broth dilution Sensititre YeastOne panels, which comprised amphotericin B, 5-flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, and caspofungin. The most common species in all age groups was C. albicans (n = 93, 65%), followed by C. glabrata (n = 27, 19%) and C. parapsilosis (n = 15, 10%). C. glabrata was mostly found in elderly individuals, while C. parapsilosis was found mainly in young children (p = 0.008). Antifungal resistance was low in the Candida species, except for reduced susceptibility to fluconazole among C. glabrata strains. C. albicans is the most frequent colonizer of Swedish patients. In general antifungal resistance is uncommon in Candida species. Nevertheless, reduced susceptibilities to fluconazole and echinocandins were found in C. glabrata and C. parapsilosis, respectively.

Indexed as

AdolescentAdultAgedAged, 80 and overAmphotericin BAnidulafunginAntifungal AgentsCandidaCandida albicansCandida glabrataCandida parapsilosisCandidemiaCaspofunginChildChild, PreschoolFemaleAmphotericin BAnidulafunginAntifungal AgentsCaspofunginFluconazoleFlucytosineItraconazoleMicafunginposaconazoleTriazolesVoriconazole

Identifiers

PMID30846717
PMCPMC6405987
OpenAlexW2919717710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.