ArticleScientific reports2019
Deep-tissue optical imaging of near cellular-sized features.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
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- MRI detection of senescent cells in porcine knee joints with a β-galactosidase responsive Gd-chelate.Npj imaging · 2025Article
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- Recent advances of photoresponsive nanomaterials for diagnosis and treatment of acute kidney injury.Journal of nanobiotechnology · 2024Review
- High Quantum Yields and Biomedical Fluorescent Imaging Applications of Photosensitized Trivalent Lanthanide Ion-Based Nanoparticles.International journal of molecular sciences · 2024Review
- Biorobotic Drug Delivery for Biomedical Applications.Molecules (Basel, Switzerland) · 2024Review
- Cytometry in the Short-Wave Infrared.ACS nano · 2024Article
- Near-infrared light-responsive hydrogels for on-demand dual delivery of proangiogenic growth factors.Acta biomaterialia · 2024Article
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- A review on selenium and gold nanoparticles combined photodynamic and photothermal prostate cancer tumors ablation.Discover nano · 2023Review
- Real-time imaging of dynamic tissues.Nature methods · 2023Article
- Miniature side-view dual axes confocal endomicroscope for repetitive in vivo imaging.Biomedical optics express · 2023Article
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- Luminescent Gold Nanoclusters for Bioimaging: Increasing the Ligand Complexity.Nanomaterials (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Detection of biological features at the cellular level with sufficient sensitivity in complex tissue remains a major challenge. To appreciate this challenge, this would require finding tens to hundreds of cells (a 0.1 mm tumor has ~125 cells), out of ~37 trillion cells in the human body. Near-infrared optical imaging holds promise for high-resolution, deep-tissue imaging, but is limited by autofluorescence and scattering. To date, the maximum reported depth using second-window near-infrared (NIR-II: 1000-1700 nm) fluorophores is 3.2 cm through tissue. Here, we design an NIR-II imaging system, "Detection of Optically Luminescent Probes using Hyperspectral and diffuse Imaging in Near-infrared" (DOLPHIN), that resolves these challenges. DOLPHIN achieves the following: (i) resolution of probes through up to 8 cm of tissue phantom; (ii) identification of spectral and scattering signatures of tissues without a priori knowledge of background or autofluorescence; and (iii) 3D reconstruction of live whole animals. Notably, we demonstrate noninvasive real-time tracking of a 0.1 mm-sized fluorophore through the gastrointestinal tract of a living mouse, which is beyond the detection limit of current imaging modalities.
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