ArticleNature communications2019
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 398 papers, 8 of them syntheses that pooled it.
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398citing papers in PubMed, 8 pooled it
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Who cites it
398 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Photobiomodulation and sleep quality: systematic review and meta-analysis.Lasers in medical science · 2026Pooled it
- Identifying novel gene dysregulation associated with opioid overdose death: a meta-analysis of differential gene expression in human prefrontal cortex.Translational psychiatry · 2026Pooled it
- Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.Atherosclerosis · 2026Pooled it
- Assessment of bidirectional relationships between sleep traits and frailty: A bidirectional Mendelian randomization study.Medicine · 2025Pooled it
- Genetic overlap and causality between depression and preterm birth: a large-scale genome-wide cross-trait analysis.Psychological medicine · 2025Pooled it
- Associations between sleep traits and colorectal cancer: a mendelian randomization analysis.Frontiers in oncology · 2025Pooled it
- Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways.BMC gastroenterology · 2024Pooled it
- Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis.Biology of sex differences · 2024Pooled it
- Molecular correlates of sleep deprivation in the mouse brain identified by meta-analysis of microarray data.Neurobiology of sleep and circadian rhythms · 2026Article
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- Genetically supported targets and drug repurposing for sleep disorders: a Mendelian randomization systematic study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Epigenetic Insights and Exosome-Based Therapeutics for Insomnia: Bridging Sleep Biology and Precision Medicine.Molecular neurobiology · 2026Review
- Emerging genetics of sleep and circadian disorders.Current opinion in pediatrics · 2026Article
- Dissecting the shared genetic architecture and biological mechanisms linking sleep traits and suicide attempts: from variants to genes.Molecular psychiatry · 2026Article
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- Association between habitual sleep duration and Alzheimer's disease: A cross-sectional study based on NHANES 2007-2018.Medicine · 2026Article
- Genetic evidence for the associations of sleep patterns with cognitive function in older adults: insights from polygenic scores in the Taiwan biobank.European archives of psychiatry and clinical neuroscience · 2026Article
- The combined association between sleep duration and insomnia symptoms with dementia and cognitive deficits: a multivariable-adjusted and genetic liability study.GeroScience · 2026Article
- Detecting the Non-Dipper Phenotype in Adolescents Exposed to Nighttime Screen Use-Digital Chronotoxicity as a Proposed Integrative Framework: A Narrative Review of Ambulatory Blood Pressure Monitoring, Subclinical Biomarkers, and Emerging Wearable and AI-Based Screening.Diagnostics (Basel, Switzerland) · 2026Review
- Obesity, Lifestyle Habits and Nutrients in Relation to Oral Ulcers: A Comprehensive Mendelian Randomization Study.Health science reports · 2026Article
338 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors.
Hassan S DashtiCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.ORCID http://orcid.org/0000-0002-1650-679X
Samuel E JonesGenetics of Complex Traits, University of Exeter Medical School, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-0153-922X
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, Exeter, EX2 5DW, UK.
Jacqueline M LaneCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.
Vincent T van HeesNetherlands eScience Center, Amsterdam, 1098 XG, The Netherlands.ORCID http://orcid.org/0000-0003-0182-9008
Heming WangBroad Institute, Cambridge, 02142, MA, USA.ORCID http://orcid.org/0000-0002-1486-7495
Jessica A RhodesCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.
Yanwei SongCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.ORCID http://orcid.org/0000-0002-2411-6548
Krunal PatelCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.
Simon G AndersonDivision of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0002-8896-073X
Robin N BeaumontGenetics of Complex Traits, University of Exeter Medical School, Exeter, EX2 5DW, UK.
David A BechtoldDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0001-8676-8704
Jack BowdenMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
Brian E CadeBroad Institute, Cambridge, 02142, MA, USA.
Marta GarauletDepartment of Physiology, University of Murcia, Murcia, 30100, Spain.
Simon D KyleSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 7LF, UK.
Max A LittleDepartment of Mathematics, Aston University, Birmingham, B4 7ET, UK.ORCID http://orcid.org/0000-0002-1507-3822
Andrew S LoudonDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.
Annemarie I LuikSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 7LF, UK.
Frank A J L ScheerBroad Institute, Cambridge, 02142, MA, USA.ORCID http://orcid.org/0000-0002-2014-7582
Kai SpiegelhalderClinic for Psychiatry and Psychotherapy, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.
Jessica TyrrellGenetics of Complex Traits, University of Exeter Medical School, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0002-9256-6065
Daniel J GottliebDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, 02115, MA, USA.
Henning TiemeierDeprtment of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, 02115, MA, USA.
David W RayDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0002-4739-6773
Shaun M PurcellDepartment of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, 02115, Boston, MA, USA.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, Exeter, EX2 5DW, UK.
Susan RedlineDepartments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 02115, MA, USA.
Deborah A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.ORCID http://orcid.org/0000-0002-6793-2262
Martin K RutterDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, Exeter, EX2 5DW, UK.
Richa SaxenaCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA. rsaxena@partners.org.ORCID http://orcid.org/0000-0003-2233-1065
Funding
TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5MPhenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2MLeveraging Family Data to Identify Genetic Variants for Sleep ApneaR01HL113338 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIN, XIHONG, REDLINE, SUSAN S. · 2012 to 2016
$4.4MGenetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0MMelatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8MImpact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2MSLEEP HEART HEALTH STUDYU01HL053941 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI O'CONNOR, GEORGE T · 1994 to 2007
$1.4MGenetic and molecular basis of circadian rhythm disordersK01HL136884 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2018 to 2022
$848kWhole Genomic Characterization of Sleep Apnea Traits and Comorbid DisordersK01HL135405 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CADE, BRIAN EDMAND · 2017 to 2020
$695kGenome-wide association study of sleep spindles and related polysomnography measuresR03MH108908 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI PURCELL, SHAUN M · 2016 to 2017
$192kImpact of genetic variants on sleep timing and type 2 diabetes riskF32DK102323 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2015 to 2016
$116kMedical Research Council MC_UU_00011/2Medical Research Council MC_UU_00011/6Medical Research Council MR/M005070/1Medical Research Council MR/P012167/1Medical Research Council MR/P023576/2NHLBI NIH HHS K01 HL135405NHLBI NIH HHS K01 HL136884NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R35 HL135818NHLBI NIH HHS T32 HL007901NHLBI NIH HHS U01 HL053941NIDDK NIH HHS F32 DK102323NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK105072NIDDK NIH HHS R01 DK107859NIMH NIH HHS R03 MH108908Wellcome Trust 107851/Z/15/Z
Abstract
Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p < 5 × 10
Indexed as
Genetic LociAccelerometryAdultAgedFemaleGenome-Wide Association StudyHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideSchizophreniaSelf ReportSleepUnited KingdomWhite People
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