ArticleNature communications2019
Mesoscopic and microscopic imaging of sensory responses in the same animal.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Trimodal ultrasound imaging of brain-tumor interaction.iScience · 2026Article
- Integration of resting-state and stimulus-fMRI uncovers reduced network flexibility in post-surgical pain.Scientific reports · 2026Article
- Action potential propagation in the rodent myelinated optic nerve does not trigger neurovascular coupling.Nature communications · 2026Article
- Biophysical simulations of fMRI responses using realistic microvascular models: Insights into distinct hemodynamics in humans and mice.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Robust single-trial decoding of physical self-motion from hemodynamic signals in the brain measured by functional ultrasound imaging.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring Neural Dynamics in the Auditory Telencephalon of Crows Using Functional Ultrasound Imaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Induction of haemodynamic travelling waves by glial-related vasomotion in a rat model of neuroinflammation: implications for functional neuroimaging.EBioMedicine · 2025Article
- Cerebral Blood Flow Responses to Trigeminal Olfactory Stimulation and Their Nicotinic Cholinergic Regulation in Anesthetized Rats.The European journal of neuroscience · 2025Article
- A Review of the Prospera Spinal Cord Stimulation System with Multiphase Stimulation and Proactive Care.Current pain and headache reports · 2025Review
- Functional ultrasound (fUS) detects mild cerebral alterations using canonical correlation analysis denoising and dynamic functional connectivity analysis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional Ultrasound Imaging Reveals Activation Properties of Clinical Spinal Cord Stimulation Therapy Programming.Journal of pain research · 2025Article
- Distal activity patterns shape the spatial specificity of neurovascular coupling.Nature neuroscience · 2024Article
- Neurovascular coupling during hypercapnia in cerebral blood flow regulation.Nature communications · 2024Article
- Neurovascular coupling and CONature communications · 2024Article
- Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The COMBO window: A chronic cranial implant for multiscale circuit interrogation in mice.PLoS biology · 2024Article
- Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells.Nature communications · 2024Article
- Specific and Nonuniform Brain States during Cold Perception in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Influence of age on nicotinic cholinergic regulation of blood flow in rat's olfactory bulb and neocortex.The journal of physiological sciences : JPS · 2024Review
- Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks.Journal of neuroscience methods · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imaging based on blood flow dynamics is widely used to study sensory processing. Here we investigated the extent to which local neuronal and capillary responses (two-photon microscopy) are correlated to mesoscopic responses detected with fast ultrasound (fUS) and BOLD-fMRI. Using a specialized chronic olfactory bulb preparation, we report that sequential imaging of the same mouse allows quantitative comparison of odour responses, imaged at both microscopic and mesoscopic scales. Under these conditions, functional hyperaemia occurred at the threshold of neuronal activation and fUS-CBV signals could be detected at the level of single voxels with activation maps varying according to blood velocity. Both neuronal and vascular responses increase non-linearly as a function of odour concentration, whereas both microscopic and mesoscopic vascular responses are linearly correlated to local neuronal calcium. These data establish strengths and limits of mesoscopic imaging techniques to report neural activity.
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