ArticleNature communications2019
Evidence for model-based encoding of Pavlovian contingencies in the human brain.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The role of selective attention in value-modulated attentional capture.Psychonomic bulletin & review · 2026Article
- Model-Free and Model-Based Learning in Human Fear Conditioning.Psychophysiology · 2026Article
- Value-modulated attentional capture depends on awareness.Psychonomic bulletin & review · 2025Article
- Higher motivation and pleasure scores predict more reliance on model-free decision making.Cognitive, affective & behavioral neuroscience · 2025Article
- Model-based and model-free valuation signals in the human brain vary markedly in their relationship to individual differences in behavioral control.bioRxiv : the preprint server for biology · 2025Article
- Distributed midbrain responses signal the content of positive identity prediction errors.Current biology : CB · 2024Article
- Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks.Nature communications · 2024Article
- Functional Connectivity Mechanisms Underlying Symptom Reduction Following Lisdexamfetamine Treatment in Binge-Eating Disorder: A Clinical Trial.Biological psychiatry global open science · 2024Article
- Neural substrates of parallel devaluation-sensitive and devaluation-insensitive Pavlovian learning in humans.Nature communications · 2023Article
- Review
- Brain System for Social Categorization by Narrative Roles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Differential Contributions of Ventral Striatum Subregions to the Motivational and Hedonic Components of the Affective Processing of Reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Predictive Representations in Hippocampal and Prefrontal Hierarchies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Reinforcement-learning in fronto-striatal circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning.Frontiers in behavioral neuroscience · 2022Article
- To be specific: The role of orbitofrontal cortex in signaling reward identity.Behavioral neuroscience · 2021Review
- Revaluing the Role of vmPFC in the Acquisition of Pavlovian Threat Conditioning in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Network organization during probabilistic learning via taste outcomes.Physiology & behavior · 2020Article
- Threat Prediction from Schemas as a Source of Bias in Pain Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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Authors and funding
5 authors.
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Abstract
Prominent accounts of Pavlovian conditioning successfully approximate the frequency and intensity of conditioned responses under the assumption that learning is exclusively model-free; that animals do not develop a cognitive map of events. However, these model-free approximations fall short of comprehensively capturing learning and behavior in Pavlovian conditioning. We therefore performed multivoxel pattern analysis of high-resolution functional MRI data in human participants to test for the encoding of stimulus-stimulus associations that could support model-based computations during Pavlovian conditioning. We found that dissociable sub-regions of the striatum encode predictions of stimulus-stimulus associations and predictive value, in a manner that is directly related to learning performance. Activity patterns in the orbitofrontal cortex were also found to be related to stimulus-stimulus as well as value encoding. These results suggest that the brain encodes model-based representations during Pavlovian conditioning, and that these representations are utilized in the service of behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.