SynthesisTranslational psychiatry2019
Motor cortex excitability and inhibitory imbalance in autism spectrum disorder assessed with transcranial magnetic stimulation: a systematic review.
Synthesis in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 76 citations in OpenAlex.
- Accelerated continuous theta burst stimulation targeting left primary motor cortex for children with autism spectrum disorder: multicentre randomised sham controlled trial.BMJ (Clinical research ed.) · 2026Trial
- Feasibility and Tolerability of Daily Theta Burst Stimulation in Autistic Youth with Intellectual Disabilities and Minimally Speaking Status: A Pilot Double-Blind Randomized Sham-Controlled Trial.Journal of autism and developmental disorders · 2025Trial
- Genetic and pharmacological evidence linking CB1R signaling to hippocampal GABAergic dysfunction in ASD mouse model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Chronological Age and Adaptive Outcomes Following Neuropsychomotor and Aquatic Interventions in Children with Autism: A Secondary Analysis.Children (Basel, Switzerland) · 2026Article
- The Hidden Architecture of Brain Structural Variability in 22q11.2 Deletion Syndrome: A Multi-site Study.medRxiv : the preprint server for health sciences · 2026Article
- Transcranial Magnetic Stimulation Combined with Nursing Intervention in Children with Autism Spectrum Disorder and Its Effects on Developmental Quotient and Serum Neurotransmitters.Journal of multidisciplinary healthcare · 2026Article
- GABAergic and glutamatergic mechanisms of cortical excitability shape motor resonance during action observation as measured by transcranial magnetic stimulation.Frontiers in human neuroscience · 2026Article
- Review
- The interplay between functional connectivity of medial and lateral visual networks, behavioral measures, and oxytocin receptor gene polymorphism (rs2254298) in autism.European child & adolescent psychiatry · 2025Article
- Validation of an electroencephalography data assimilation-based computational approach for estimating cortical excitation-inhibition balance.Communications engineering · 2025Article
- Opposing Modulation of EEG Aperiodic Component by Ketamine and Thiopental: Implications for the Noninvasive Assessment of Cortical E/I Balance in Humans.Research square · 2025Article
- Multimodal Morphometric Similarity Network Analysis of Autism Spectrum Disorder.Brain sciences · 2025Article
- Neuroplasticity-based novel brain stimulation support intervention options for autistic population.Frontiers in human neuroscience · 2025Article
- rTMS-induced neuroimaging changes measured with structural and functional MRI in autism.Frontiers in neuroscience · 2025Article
- Article
- Low-level brain somatic mutations in exonic regions are collectively implicated in autism with germline mutations in autism risk genes.Experimental & molecular medicine · 2024Article
- A systematic review of transcranial magnetic stimulation treatment for autism spectrum disorder.Heliyon · 2024Review
- Article
- WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice.Neuroscience bulletin · 2023Article
- NLRP3-GABA signaling pathway contributes to the pathogenesis of impulsive-like behaviors and cognitive deficits in aged mice.Journal of neuroinflammation · 2023Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Cortical excitation/inhibition (E/I) imbalances contribute to various clinical symptoms observed in autism spectrum disorder (ASD). However, the detailed pathophysiologic underpinning of E/I imbalance remains uncertain. Transcranial magnetic stimulation (TMS) motor-evoked potentials (MEP) are a non-invasive tool for examining cortical inhibition in ASD. Here, we conducted a systematic review on TMS neurophysiology in motor cortex (M1) such as MEPs and short-interval intracortical inhibition (SICI) between individuals with ASD and controls. Out of 538 initial records, we identified six articles. Five studies measured MEP, where four studies measured SICI. There were no differences in MEP amplitudes between the two groups, whereas SICI was likely to be reduced in individuals with ASD compared with controls. Notably, SICI largely reflects GABA(A) receptor-mediated function. Conversely, other magnetic resonance spectroscopy and postmortem methodologies assess GABA levels. The present review demonstrated that there may be neurophysiological deficits in GABA receptor-mediated function in ASD. In conclusion, reduced GABAergic function in the neural circuits could underlie the E/I imbalance in ASD, which may be related to the pathophysiology of clinical symptoms of ASD. Therefore, a novel treatment that targets the neural circuits related to GABA(A) receptor-mediated function in regions involved in the pathophysiology of ASD may be promising.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.