Evidence map›Paper›PMID 30846564›Full record

ArticleThe Journal of biological chemistry2019

Discovery and structure of the antimicrobial lasso peptide citrocin.

Wai Ling Cheung-Lee, Madison E Parry, Alexis Jaramillo Cartagena, Seth A Darst, A James Link

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 84 citations in OpenAlex.

  1. Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026
    Review
  2. A One Health Perspective onMicroorganisms · 2026
    Review
  3. Article
  4. Review
  5. Lasso Peptides-A New Weapon Against Superbugs.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides.Angewandte Chemie (International ed. in English) · 2025
    Article
  9. Lasso peptides: A focus on therapeutic index.World journal of microbiology & biotechnology · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. The Anti-Microbial Peptide Citrocin ControlsInternational journal of molecular sciences · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Mutexa: A Computational Ecosystem for Intelligent Protein Engineering.Journal of chemical theory and computation · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Wai Ling Cheung-LeeFrom the Departments of Chemical and Biological Engineering.ORCID 0000-0001-7938-9001
Madison E ParryFrom the Departments of Chemical and Biological Engineering.
Alexis Jaramillo Cartagenathe Laboratory of Molecular Biophysics and Tri-Institutional Training Program in Chemical Biology, Rockefeller University, New York, New York 10065.
Seth A Darstthe Laboratory of Molecular Biophysics and Tri-Institutional Training Program in Chemical Biology, Rockefeller University, New York, New York 10065.
A James LinkFrom the Departments of Chemical and Biological Engineering, ajlink@princeton.edu.ORCID 0000-0001-5066-9691
Princeton University · USTri-Institutional PhD Program in Chemical Biology · US

Funding

Structure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9M
Lasso Peptide DiscoveryR01GM107036 · NIGMS · PRINCETON UNIVERSITY · PI LINK, AARON JAMES · 2014 to 2022
$2.9M
NIGMS NIH HHS R01 GM107036NIGMS NIH HHS R35 GM118130
6 · The paper itself

Abstract

We report the identification of citrocin, a 19-amino acid-long antimicrobial lasso peptide from the bacteria

Indexed as

Anti-Bacterial AgentsCitrobacterDrug DiscoveryDrug StabilityEscherichia coliMicrobial Sensitivity TestsMultigene FamilyMutagenesisPeptidesProtein ConformationAnti-Bacterial AgentsPeptidesantibiotic resistanceantimicrobial peptide (AMP)citrocinlasso peptidemembrane transportmicrocinnatural productnuclear magnetic resonance (NMR)peptide transportRiPPsRNA polymerase

Identifiers

PMID30846564
PMCPMC6497930
OpenAlexW2921257516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.