Observational studyJournal of the American Society of Nephrology : JASN2019
Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study.
Observational study in Journal of the American Society of Nephrology : JASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Management of blood pressure in adults, children and young people on dialysis: UK kidney association clinical practice guideline.BMC nephrology · 2025Guideline
- Evolution and change in paradigm of hemodialysis in children: a systematic review.Pediatric nephrology (Berlin, Germany) · 2021Pooled it
- Recommendations of the Brazilian Society of Nephrology for hemodiafiltration in maintenance dialysis therapy.Jornal brasileiro de nefrologiaGuideline
- Physical activity among children and young people with chronic kidney diseases: a scoping review.Pediatric nephrology (Berlin, Germany) · 2026Article
- Adequacy of dialysis in children and adolescents: more than just Kt/V.Pediatric nephrology (Berlin, Germany) · 2026Review
- Hemodiafiltration in Dialysis Practice: Global Adoption, Toxin Clearance, Inflammation Control, and Clinical Safety.Toxins · 2026Review
- Dialysis-associated cardiovascular disease risk in children: mechanism and management.Pediatric nephrology (Berlin, Germany) · 2026Review
- Medical device regulation and dialysis practice-impact on patients, doctors and manufacturers.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Review
- Comparing outcomes with different dialysis modalities in children with kidney failure: home hemodialysis versus in-center hemodiafiltration or conventional hemodialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Impact of online hemodiafiltration on bone turnover in children with CKD-5d: A prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Haemodiafiltration versus high-flux haemodialysis-a Consensus Statement from the EuDial Working Group of the ERA.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- The association between systolic and diastolic dysfunction and autonomic nervous system function in children receiving chronic hemodialysis.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Why High-Volume Post-Dilution Hemodiafiltration Should Be the New Standard in Dialysis Care: A Comprehensive Review of Clinical Outcomes and Mechanisms.Journal of clinical medicine · 2025Review
- How dialysis frequency and duration impact uremic toxin and fluid removal: a pediatric perspective.Pediatric nephrology (Berlin, Germany) · 2025Review
- High-Volume Hemodiafiltration Versus High-Flux Hemodialysis: A Narrative Review for the Clinician.Journal of clinical medicine · 2025Review
- Cognitive deterioration in patients undergoing hemodialysis: how variations in age influence the development of new mechanisms and treatment approaches?Frontiers in aging neuroscience · 2025Review
- Changes in echocardiographic parameters after hemodialysis session in a North African pediatric population with end-stage renal disease and without known heart disease.La Tunisie medicale · 2024Article
- Hemodiafiltration for children with stage 5 chronic kidney disease: technical aspects and outcomes.Pediatric nephrology (Berlin, Germany) · 2024Review
- Technical requirements and devices available for long-term hemodialysis in children-mind the gap!Pediatric nephrology (Berlin, Germany) · 2024Review
- Changes in the cardiovascular risk profile in children approaching kidney replacement therapy.EClinicalMedicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors at 20 institutions in 11 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce.
methodsThe HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. Primary outcome measures were annualized changes in carotid intima-media thickness (cIMT) SD score and height SD score.
resultsWe enrolled 190 children from 28 centers; 78 on HD and 55 on HDF completed 1-year follow-up. The groups were comparable for age, dialysis vintage, access type, dialysis frequency, blood flow, and residual renal function. At 1 year, cIMT SD score increased significantly in children on HD but remained static in the HDF cohort. On propensity score analysis, HD was associated with a +0.47 higher annualized cIMT SD score compared with HDF. Height SD score increased in HDF but remained static in HD. Mean arterial pressure SD score increased with HD only. Factors associated with higher cIMT and mean arterial pressure SD-scores were HD group, higher ultrafiltration rate, and higher
conclusionsHDF is associated with a lack of progression in vascular measures versus progression with HD, as well as an increase in height not seen in the HD cohort. Patient-related outcomes improved among children on HDF correlating with improved BP control and clearances. Confirmation through randomized trials is required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.