ArticleProceedings of the National Academy of Sciences of the United States of America2019
Role of contacts in long-range protein conductance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Nonuniform Distance Decay of Conductance in a Series of Multiheme Cytochrome Bioelectronic Junctions.The journal of physical chemistry letters · 2026Article
- Real-time electrical monitoring of enzymatic catalytic dynamics at the single-molecule level.Nature communications · 2026Article
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
- Article
- Conducting Atomic Force Microscopy of Protein Wires.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Article
- Scanning Tunneling Microscope Measurement of Proteasome Conductance.Biomolecules · 2025Article
- On Emergence of Spontaneous Oscillations in Kombucha and Proteinoids.BioNanoScience · 2025Review
- Holographic nature of critical quantum states of proteins.Computational and structural biotechnology journal · 2025Article
- Conductance Channels in a Single-Entity Enzyme.The journal of physical chemistry letters · 2024Article
- Computation of biological conductance with Liouville quantum master equation.Scientific reports · 2024Article
- Electron transport through two interacting channels in Azurin-based solid-state junctions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Shallow conductance decay along theChemical science · 2024Article
- Secondary structure determines electron transport in peptides.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Single-Molecule Electrical Profiling of Peptides and Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Heavy Water Reduces the Electronic Conductance of Protein Wires via Deuteron Interactions with Aromatic Residues.Nano letters · 2023Article
- Long-Range Conductivity in Proteins Mediated by Aromatic Residues.ACS physical chemistry Au · 2023Article
- DNA nanopores as artificial membrane channels for bioprotonics.Nature communications · 2023Article
- Fabrication of electron tunneling probes for measuring single-protein conductance.Nature protocols · 2023Review
- Direct biomolecule discrimination in mixed samples using nanogap-based single-molecule electrical measurement.Scientific reports · 2023Article
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7 authors.
Funding
Abstract
Proteins are widely regarded as insulators, despite reports of electrical conductivity. Here we use measurements of single proteins between electrodes, in their natural aqueous environment to show that the factor controlling measured conductance is the nature of the electrical contact to the protein, and that specific ligands make highly selective electrical contacts. Using six proteins that lack known electrochemical activity, and measuring in a potential region where no ion current flows, we find characteristic peaks in the distributions of measured single-molecule conductances. These peaks depend on the contact chemistry, and hence, on the current path through the protein. In consequence, the measured conductance distribution is sensitive to changes in this path caused by ligand binding, as shown with streptavidin-biotin complexes. Measured conductances are on the order of nanosiemens over distances of many nanometers, orders of magnitude more than could be accounted for by electron tunneling. The current is dominated by contact resistance, so the conductance for a given path is independent of the distance between electrodes, as long as the contact points on the protein can span the gap between electrodes. While there is no currently known biological role for high electronic conductance, its dependence on specific contacts has important technological implications, because no current is observed at all without at least one strongly bonded contact, so direct electrical detection is a highly selective and label-free single-molecule detection method. We demonstrate single-molecule, highly specific, label- and background free-electronic detection of IgG antibodies to HIV and Ebola viruses.
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