Evidence map›Paper›PMID 30846504›Full record

ArticleHaematologica2019

Christmas disease in a Hovawart family resembling human hemophilia B Leyden is caused by a single nucleotide deletion in a highly conserved transcription factor binding site of the

Bertram Brenig, Lilith Steingräber, Shuwen Shan, Fangzheng Xu, Marc Hirschfeld, Reiner Andag, Mirjam Spengeler, Elisabeth Dietschi, Reinhard Mischke, Tosso Leeb

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. One Health: Animal Models of Heritable Human Bleeding Diseases.Animals : an open access journal from MDPI · 2022
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Bertram BrenigUniversity of Göttingen, Institute of Veterinary Medicine, Göttingen, Germany bbrenig@gwdg.de.
Lilith SteingräberUniversity of Göttingen, Institute of Veterinary Medicine, Göttingen, Germany.
Shuwen ShanUniversity of Göttingen, Institute of Veterinary Medicine, Göttingen, Germany.
Fangzheng XuUniversity of Göttingen, Institute of Veterinary Medicine, Göttingen, Germany.
Marc HirschfeldUniversity of Göttingen, Institute of Veterinary Medicine, Göttingen, Germany.
Reiner AndagUniversity Medical Center Göttingen, Institute for Clinical Chemistry, Göttingen, Germany.
Mirjam SpengelerInstitute of Genetics, University of Bern, Bern, Switzerland.
Elisabeth DietschiInstitute of Genetics, University of Bern, Bern, Switzerland.
Reinhard MischkeSmall Animal Clinic, University of Veterinary Medicine Hannover Foundation, Hannover, Germany.
Tosso LeebInstitute of Genetics, University of Bern, Bern, Switzerland.
University of Göttingen · DEUniversity of Bern · CHUniversitätsmedizin Göttingen · DEUniversity Medical Center Freiburg · DEUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophilia B is a classical monogenic, X-chromosomal, recessively transmitted bleeding disorder caused by genetic variants within the coagulation factor IX gene (

Indexed as

Point MutationPromoter Regions, GeneticSequence DeletionAnimalsBinding SitesDog DiseasesDogsFactor IXGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHemophilia BPedigreePhenotypeFactor IXTranscription Factors

Identifiers

PMID30846504
PMCPMC6821609
OpenAlexW2949169082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.