ArticleHaematologica2019
Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling.
Abstract readLetter
In one paragraph
Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Distinct bone marrow immunophenotypic features define the splicing factor 3B subunit 1 (SF3B1)-mutant myelodysplastic syndromes subtype.British journal of haematology · 2021Trial
- Targeting TGFBR1 with the Investigational Inhibitor TP-6379 Improves Hematopoiesis in Low-Risk MDS Ex Vivo.Cells · 2026Article
- Alternative splicing of toll-like receptor pathway mRNAs in lung immune cells from patients with ARDS.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma.British journal of cancer · 2026Article
- Weakened macrophage antibacterial capacity in myelodysplastic syndrome.ImmunoHorizons · 2026Article
- Gene Expression and Alternative Splicing Throughout the Reproductive Cycle of a Viviparous Lizard Reveal Novel Genes for Pregnancy and Convergence With Squamates and Mammals.Molecular ecology · 2026Article
- Variant-specific SF3B1 mutations drive distinct splicing and mitochondrial dysfunction in myelodysplastic neoplasms.Human genomics · 2026Article
- Vulnerability of SRSF2-mutated chronic myelomonocytic leukemia to perturbation of the cGAS-STING pathway.Blood advances · 2026Article
- Clonal Hematopoiesis and Incident Heart Failure.JAMA cardiology · 2026Article
- A Pilot Study on Early-Phase Efficacy and Biomarker Analysis of Cervical Intralymphatic Immunotherapy for Seasonal Rhinoconjunctivitis.Journal of asthma and allergy · 2026Article
- asxl1 C-terminal truncation and SRSF2 mutation drive leukemogenesis via immune reprogramming.Leukemia · 2025Article
- Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy.Cell reports. Medicine · 2025Article
- Association of clonal hematopoiesis of indeterminate potential with cardiometabolic multimorbidity progression and mortality: a prospective study of UK Biobank.European journal of medical research · 2025Article
- Identification of new candidate drugs in myelodysplastic syndromes with splicing factor mutations by transcriptional profiling and connectivity map analysis.British journal of haematology · 2025Article
- Low-risk MDS-A spotlight on precision medicine forHemaSphere · 2025Review
- Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study.Cardiovascular diabetology · 2025Article
- Pathogenesis and inflammaging in myelodysplastic syndrome.Haematologica · 2025Review
- SF3B1K700E mutation in human embryonic stem cells causes aberrant expression of immune-related genes.PloS one · 2025Article
- VEXAS syndrome: is it more a matter of inflammation or hematopoietic clonality? A case series approach to diagnosis, therapeutic strategies and transplant management.Annals of hematology · 2025Article
- Proteomic Profile Regulated by the Immunomodulatory Jusvinza Drug in Neutrophils Isolated from Rheumatoid Arthritis Patients.Biomedicines · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Daniel A PollyeaDivision of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.
Chelsea HarrisDepartment of Biomedical Research, National Jewish Health, Denver, CO.
Jennifer L RabeDivision of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.
Brenna R HedinDepartment of Biomedical Research, National Jewish Health, Denver, CO.
Lesly De ArrasCenter for Genes, Environment and Health, National Jewish Health, Denver, CO.
Sigrid KatzDivision of Hematology and Oncology, University of California, San Diego, La Jolla, CA.
Emily WheelerDivision of Hematology and Oncology, University of California, San Diego, La Jolla, CA.
Rafael BejarDivision of Hematology and Oncology, University of California, San Diego, La Jolla, CA.
Matthew J WalterDivision of Oncology, Department of Medicine, Washington University, St. Louis, MO.
Craig T JordanDivision of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.
Eric M PietrasDivision of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.
Scott AlperDepartment of Biomedical Research, National Jewish Health, Denver, CO alpers@njhealth.org.
Funding
Specimen Acquistition and Expression ProfilingP01CA101937 · NCI · WASHINGTON UNIVERSITY · PI LEY, TIMOTHY J. · 2003 to 2023
$58.8MImpact of IL-1 signaling on hematopoietic stem cell function and emergence of clonal hematopoiesis.R01DK119394 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2019 to 2023
$2.0MToxin-induced alternative mRNA splicing in Toll-like receptor signaling pathwaysR01ES025161 · NIEHS · NATIONAL JEWISH HEALTH · PI ALPER, SCOTT · 2016 to 2020
$1.8MPro-inflammatory cytokines in hematopoietic stem cell functionK01DK098315 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2014 to 2018
$691kNCI NIH HHS P01 CA101937NIDDK NIH HHS K01 DK098315NIDDK NIH HHS R01 DK119394NIEHS NIH HHS R01 ES025161
Abstract
PubMed holds no abstract for this paper.
Indexed as
Immunity, InnateAnimalsCytokinesHumansInflammationK562 CellsLipopolysaccharidesMiceMutationMyelodysplastic SyndromesNF-kappa B p50 SubunitPhenotypePhosphoproteinsRAW 264.7 CellsRNA SplicingRNA Splicing FactorsCytokinesLipopolysaccharidesNF-kappa B p50 SubunitNFKB1 protein, humanNfkb1 protein, mousePhosphoproteinsRNA Splicing FactorsSerine-Arginine Splicing FactorsSF3B1 protein, humanSf3b1 protein, mouseSplicing Factor U2AFSRSF2 protein, humanSRSF2 protein, mouseU2AF1 protein, humanZrsr1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.