ArticleThe European respiratory journal2019
Xenon-129 MRI detects ventilation deficits in paediatric stem cell transplant patients unable to perform spirometry.
Article in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04029636 (Hyperpolarized 129Xe Magnetic Resonance Imaging for the Early Detection of Bronchiolitis Obliterans Syndrome), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hyperpolarized 129Xe Magnetic Resonance Imaging for the Early Detection of Bronchiolitis Obliterans Syndrome (BOS) and Other Late Onset Non-infectious Pulmonary Complications (LONIPCs) Following Hematopoietic Stem Cell Transplantation
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Taiwan consensus on pulmonary chronic graft-versus-host disease: A joint statement from the Taiwan Society of Blood and Marrow Transplantation (TBMT) and Taiwan Society of Pulmonary and Critical Care Medicine (TSPCCM).British journal of haematology · 2025Guideline
- A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging.Journal of magnetic resonance imaging : JMRI · 2025Pooled it
- Diagnostic accuracy of ultrashort echo times-MRI in patients with and without idiopathic pulmonary fibrosis.European radiology · 2026Article
- Structural and Functional Pulmonary MRI to Predict Pulmonary Exacerbations in Cystic Fibrosis.Chest · 2026Article
- Characterization of Pulmonary Dysfunction in Systemic Juvenile Idiopathic Arthritis Using Xenon and Proton MRI.Pediatric pulmonology · 2026Article
- Comparing Mean-anchored Generalized Linear Binning with Established Methods to Quantify Xenon-129 Ventilation Defect Percentage.Academic radiology · 2026Article
- Comparative evaluation of supervised and unsupervised deep learning strategies for denoising hyperpolarizedMagnetic resonance in medicine · 2026Article
- Establishing standardized healthy reference distributions and values for multisiteMagnetic resonance in medicine · 2025Article
- Addressing Knowledge Gaps in the Early Detection of Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-versus-Host Disease Survivorship after Hematopoietic Cell Transplantation: Part II. Organ Dysfunction and Immune Reconstitution Considerations for Children with Chronic Graft-versus-Host Disease after Hematopoietic Cell Transplantation.Transplantation and cellular therapy · 2025Article
- Quantifying Spatial Distribution of Ventilation Defects in Multiple Pulmonary Diseases With HyperpolarizedJournal of magnetic resonance imaging : JMRI · 2025Article
- Clinical impact of airflow obstruction after allogeneic hematopoietic stem cell transplantation.International journal of hematology · 2024Article
- Innovations in Childhood Interstitial and Diffuse Lung Disease.Clinics in chest medicine · 2024Review
- HyperpolarizedJHLT open · 2024Article
- Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation.Journal of visualized experiments : JoVE · 2023Article
- Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation.Journal of visualized experiments : JoVE · 2023Article
- Article
- Monitoring and Management of Respiratory Function in Pompe Disease: Current Perspectives.Therapeutics and clinical risk management · 2023Review
- Seeing Premature Lung Disease: Hyperpolarized Xe Magnetic Resonance Imaging.American journal of respiratory and critical care medicine · 2023Article
- PediatricJournal of magnetic resonance imaging : JMRI · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEarly detection of pulmonary morbidity following haematopoietic stem cell transplantation (HSCT) remains an important challenge for intervention, primarily due to the insensitivity of spirometry to early change, and in paediatrics, patient compliance provides additional challenges. Regional lung ventilation abnormalities in paediatric HSCT patients were quantified using hyperpolarised xenon-129 (
methodsMedically stable, paediatric allogeneic HSCT patients (n=23, ages 6-16 years) underwent an outpatient MRI scan where regional ventilation was quantified with a breath-hold of hyperpolarised
resultsThe mean±sd
conclusionLung ventilation deficits were detected using hyperpolarised
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.