Evidence map›Paper›PMID 30846463›Full record

ArticleDevelopment (Cambridge, England)2019

Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells.

Santhosh V Kumar, Pei X Er, Kynan T Lawlor, Ali Motazedian, Michelle Scurr, Irene Ghobrial, Alexander N Combes, Luke Zappia, Alicia Oshlack, Edouard G Stanley and 1 more

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed.

  1. Article
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  5. Review
  6. [Establishment of an Epstein-Barr virus infection model using human nasal organoids].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Article
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  12. Developmental Hypoxia Enhances Kidney Organoid Complexity and Maturity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Pluripotent stem cell-derived organoids: A brief history of curiosity-led discoveries.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  20. Measurement of adhesion and traction of cells at high yield reveals an energetic ratchet operating during nephron condensation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Santhosh V KumarMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.ORCID 0000-0002-7303-1938
Pei X ErMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.
Kynan T LawlorMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.
Ali MotazedianMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.
Michelle ScurrMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.
Irene GhobrialMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.
Alexander N CombesMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.
Luke ZappiaMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.
Alicia OshlackMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.
Edouard G StanleyMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia.
Melissa H LittleMurdoch Children's Research Institute, Flemington Rd, Parkville, Victoria 3052, Australia melissa.little@mcri.edu.au.ORCID 0000-0003-0380-2263

Funding

Generating kidney organoids and mature renal cell types via directed iPSC differentiationUH3DK107344 · NIDDK · MURDOCH CHILDREN'S RESEARCH INSTITUTE · PI LITTLE, MELISSA HELEN · 2017 to 2019
$1.0M
Generating kidney organoids and mature renal cell types via directed iPSC differentiationUH2DK107344 · NIDDK · MURDOCH CHILDREN'S RESEARCH INSTITUTE · PI LITTLE, MELISSA HELEN · 2015 to 2016
$691k
NIDDK NIH HHS UH2 DK107344NIDDK NIH HHS UH3 DK107344
6 · The paper itself

Abstract

Kidney organoids have potential uses in disease modelling, drug screening and regenerative medicine. However, novel cost-effective techniques are needed to enable scaled-up production of kidney cell types

Indexed as

Cell Culture TechniquesGene Expression Regulation, DevelopmentalAlbuminsCell DifferentiationCells, CulturedDoxorubicinHumansKidneyNephronsOrganoidsPluripotent Stem CellsSignal TransductionTranscription, GeneticWnt ProteinsAlbuminsDoxorubicinWnt ProteinsKidneyKidney micro-organoidNephronOrganoidPluripotent stem cellSingle cell profilingSuspension culture

Identifiers

PMID30846463
PMCPMC6432662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.