ArticleTicks and tick-borne diseases2019
Vertical transmission rates of Borrelia miyamotoi in Ixodes scapularis collected from white-tailed deer.
Article in Ticks and tick-borne diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Lyme Disease and Other Tick-Borne Infections.Current neurology and neuroscience reports · 2026Review
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- Occurrence of Borrelia miyamotoi in Ixodes ricinus and Dermacentor reticulatus ticks removed from human skin in Poland in 2022-2024.Scientific reports · 2026Article
- Establishment of a laboratory mouse model to studyFrontiers in immunology · 2026Article
- Experimental transmission of the relapsing fever spirochete Borrelia persica in its tick vector Ornithodoros tholozani by transstadial, transovarial, and hyperparasitism routes with description of dynamics within the tick host.Parasites & vectors · 2025Article
- A mechanistic model explains variation in larval tick questing phenology along an elevation gradient.Royal Society open science · 2025Article
- Spatial and temporal distribution of Ixodes scapularis and tick-borne pathogens across the northeastern United States.Parasites & vectors · 2024Article
- Combining short- and long-read sequencing unveils geographically structured diversity iniScience · 2024Article
- Laboratory Management of Mammalian Hosts forComparative medicine · 2024Review
- Systematic investigation of theOne health (Amsterdam, Netherlands) · 2024Article
- Review
- Neuropsychiatric Symptoms and Tick-Borne Diseases.Current topics in behavioral neurosciences · 2023Article
- Tick Species Composition, Collection Rates, and Phenology Provide Insights into Tick-Borne Disease Ecology in Virginia.Journal of medical entomology · 2022Article
- Tick-Borne Pathogens in Questing Blacklegged Ticks (Acari: Ixodidae) From Pike County, Pennsylvania.Journal of medical entomology · 2022Article
- A comparison of horizontal and transovarial transmission efficiency of Borrelia miyamotoi by Ixodes scapularis.Ticks and tick-borne diseases · 2022Article
- The raccoon dog (International journal for parasitology. Parasites and wildlife · 2021Article
- Monitoring Risk: Tick andPathogens (Basel, Switzerland) · 2021Article
- Transovarial Transmission ofMicroorganisms · 2021Article
- The Family Borreliaceae (Spirochaetales), a Diverse Group in Two Genera of Tick-Borne Spirochetes of Mammals, Birds, and Reptiles.Journal of medical entomology · 2021Article
- Examining Prevalence and Diversity of Tick-Borne Pathogens in Questing Ixodes pacificus Ticks in California.Applied and environmental microbiology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Borrelia miyamotoi is a relapsing fever spirochete transmitted by ticks in the Ixodes ricinus complex. In the eastern United States, B. miyamotoi is transmitted by I. scapularis, which also vectors several other pathogens including B. burgdorferi sensu stricto. In contrast to Lyme borreliae, B. miyamotoi can be transmitted vertically from infected female ticks to their progeny. Therefore, in addition to nymphs and adults, larvae can vector B. miyamotoi to wildlife and human hosts. Two widely varying filial infection prevalence (FIP) estimates - 6% and 73% - have been reported previously from two vertically infected larval clutches; to our knowledge, no other estimates of FIP or transovarial transmission (TOT) rates for B. miyamotoi have been described in the literature. Thus, we investigated TOT and FIP of larval clutches derived from engorged females collected from hunter-harvested white-tailed deer in 2015 (n = 664) and 2016 (n = 599) from Maine, New Hampshire, Tennessee, and Wisconsin. After engorged females oviposited in the lab, they (n = 492) were tested for B. miyamotoi infection by PCR. Subsequently, from each clutch produced by an infected female, larval pools, as well as 100 individual eggs or larvae, were tested. The TOT rate of the 11 infected females was 90.9% (95% CI; 57.1-99.5%) and the mean FIP of the resulting larval clutches was 84.4% (95% CI; 68.1-100%). Even though the overall observed vertical transmission rate (the product of TOT and FIP; 76.7%, 95% CI; 44.6-93.3%) was high, additional horizontal transmission may be required for enzootic maintenance of B. miyamotoi based on the results of a previously published deterministic model. Further investigation of TOT and FIP variability and the underlying mechanisms, both in nature and the laboratory, will be needed to resolve this question. Meanwhile, studies quantifying the acarological risk of Borrelia miyamotoi disease need to consider not only nymphs and adults, but larval I. scapularis as well.
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