ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Subcortical Shape Abnormalities in Bulimia Nervosa.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Aberrant large- and mesoscale network segregation and integration in bulimia nervosa.Journal of eating disorders · 2026Article
- Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Dissecting the Causal Association Between Bulimia Nervosa and Structural Brain Abnormalities: A Two-Sample Bidirectional Mendelian Randomization Study.Brain and behavior · 2025Article
- Subcortical shape biomarkers reveal limbic and basal ganglia damage in anti-LGI1 encephalitis.Frontiers in immunology · 2025Article
- Cortical thickness and childhood eating behaviors: differences according to sex and age, and relevance for eating disorders.Eating and weight disorders : EWD · 2024Article
- Exploring the thalamus: a crucial hub for brain function and communication in patients with bulimia nervosa.Journal of eating disorders · 2023Article
- Current Discoveries and Future Implications of Eating Disorders.International journal of environmental research and public health · 2023Review
- Exploration of the relationships between clinical traits and functional connectivity based on surface morphology abnormalities in bulimia nervosa.Brain and behavior · 2023Article
- Subcortical shape in pediatric and adult obsessive-compulsive disorder.Depression and anxiety · 2022Article
- Changes in cognitive and behavioral control after lamotrigine and intensive dialectical behavioral therapy for severe, multi-impulsive bulimia nervosa: an fMRI case study.Eating and weight disorders : EWD · 2022Article
- Subcortical brain volume and cortical thickness in adolescent girls and women with binge eating.The International journal of eating disorders · 2021Article
- Striatal shape alteration as a staging biomarker for Parkinson's Disease.NeuroImage. Clinical · 2020Article
- Multimodal quantitative magnetic resonance imaging alterations of the basal ganglia circuit underlie the severity of bulimia nervosa.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBulimia nervosa (BN) is associated with functional abnormalities in frontostriatal and frontolimbic circuits. Although structural alterations in the frontal portions of these circuits have been observed, this is the first study of subcortical surface morphometry and the largest study of subcortical volume in BN.
methodsAnatomical magnetic resonance scans were acquired from 62 female participants with full and subthreshold BN (mean age ± SD, 18.7 ± 4.0 years) and 65 group-matched healthy control participants (mean age ± SD, 19.3 ± 5.7 years). General linear models were used to compare groups and assess the significance of group-by-age interactions on the shape and total volume of 15 subcortical structures (p < .05, familywise error corrected). Associations with illness severity and duration were assessed in the BN group.
resultsSubcortical volumes did not differ across groups, but vertexwise analyses revealed inward shape deformations on the anterior surface of the pallidum in BN relative to control participants that were associated with binge-eating frequency and illness duration. Inward deformations on the ventrolateral thalamus and dorsal amygdala were more pronounced with advancing age in the BN group, and inward deformations on the caudate, putamen, and amygdala were associated with self-induced vomiting frequency.
conclusionsOur findings point to localized deformations on the surface of subcortical structures in areas that comprise both reward and cognitive control circuits. These deformations were more pronounced among older BN participants and among those with the most severe symptoms. Such precise localization of alterations in subcortical morphometry may ultimately aid in efforts to identify markers of risk and BN persistence.
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