ArticleJournal of the American College of Cardiology2019
Article in Journal of the American College of Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Artificial Intelligence-Based Clinical Decision-Making in Erectile Dysfunction: a Narrative Review.Current urology reports · 2024Review
- AorticJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Applications of artificial intelligence in the diagnosis and prediction of erectile dysfunction: a narrative review.International journal of impotence research · 2023Review
- Advances in the Assessment of Coronary Artery Disease Activity with PET/CT and CTA.Tomography (Ann Arbor, Mich.) · 2023Review
- Advances in positron emission tomography tracers related to vascular calcification.Annals of nuclear medicine · 2022Review
- Temporal relationship betweenJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Atherosclerosis Imaging withDiagnostics (Basel, Switzerland) · 2020Review
- Review
- Multimodality imaging: Bird's eye view from the 2019 American College of Cardiology Scientific Sessions.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- The Potential of PET in the Management of Peripheral Arterial Disease.JACC. Cardiovascular imaging · 2020Article
- Contemporary and Novel Imaging Studies for the Evaluation of Erectile Dysfunction.Medical sciences (Basel, Switzerland) · 2019Review
- Arterial erectile dysfunction is an early sign of vascular damage: the importance for the prevention of cardiovascular health.Annals of translational medicine · 2019Article
- Penile ArteryJournal of the American College of Cardiology · 2019Article
Corrections and comments
- Commented on byPenile Artery2019
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundFluorine-18 sodium fluoride (NaF), a bone-seeking radiopharmaceutical used to detect osseous metastases, localizes in regions of microcalcification in atherosclerosis.
objectivesTo determine if atherosclerosis of penile arteries plays a role in erectile dysfunction (ED), this study analyzed NaF images in prostate cancer patients.
methodsNaF positron emission tomography-computed tomography bone scans were evaluated in 437 prostate cancer patients (age 66.6 ± 8.7 years). Their urologic histories were reviewed for prevalent ED (diagnosed before the scan date) or incident ED (no ED at first scan, but developed during 1-year follow-up); patients with no ED (neither before the scan nor during follow-up) were included as a control group. A semicircular region of interest was set on the dorsal one-half of the penis (to avoid residual excreted activity in the urethra) on 5 contiguous slices at the base of the penis on positron emission tomography-computed tomography coronal reconstructions, and the average standardized uptake value (SUVmax) was described as NaF uptake.
resultsOf 437 patients, 336 (76.9%) had prevalent ED, 60 incident ED (13.7%), and 41 had no ED (9.4%). SUVmax in patients with prevalent (median 1.88; interquartile range [IQR]: 1.67 to 2.16) or incident (median 1.86; IQR: 1.72 to 2.08) ED was significantly higher than no ED (median 1.42; IQR: 1.25 to 1.54) patients (p < 0.001). After adjustment for other risk factors, the odds ratio of prevalent or incident ED was 25.2 (95% confidence interval: 9.5 to 67.0) for every 0.5-U increment in SUVmax with receptor operating characteristic area of 0.91 (95% confidence interval: 0.88 to 0.94).
conclusionsNaF uptake in penile vessels suggests that atherosclerosis is associated with ED in prostate cancer patients. The importance of NaF uptake needs to be tested in noncancer subjects and cause-effect relationship needs to be established.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.