Evidence map›Paper›PMID 30846311›Full record

ReviewTrends in microbiology2019

Commensal Staphylococci Influence Staphylococcus aureus Skin Colonization and Disease.

Corey P Parlet, Morgan M Brown, Alexander R Horswill

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The small RNA Teg16 repressesbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. mBio · 2026
    Article
  12. Article
  13. Review
  14. Beyond the skin barrier: commensalbioRxiv : the preprint server for biology · 2026
    Article
  15. Article
  16. Review
  17. Article
  18. Intracellular survival ofVirulence · 2025
    Review
  19. Review
  20. Review

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Corey P ParletUniversity of Iowa, Roy J. and Lucille A. Carver College of Medicine, Department of Microbiology, Iowa City, IA, USA.
Morgan M BrownDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Veterans Affairs Eastern Colorado Healthcare System, Aurora, CO, USA. Electronic address: alexander.horswill@ucdenver.edu.

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THOMAS, VINAI · 2009 to 2023
$32.1M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
RESEARCH TRAINING IN INFECTIOUS DISEASEST32AI007343 · NIAID · UNIVERSITY OF IOWA · PI STAPLETON, JACK T. · 1988 to 2024
$5.0M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
Impact of commensal cross-talk on MRSA colonization and infectionR21AI133089 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HORSWILL, ALEXANDER R · 2018 to 2019
$432k
Quorum Sensing Dependent Interactions with Biofilms and Innate Immunity DefensesI01BX002711 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI ALEXANDER R HORSWILL · 2015 to 2026
–
BLRD VA I01 BX002711NIAID NIH HHS P01 AI083211NIAID NIH HHS R21 AI133089NIAID NIH HHS T32 AI007343NIAID NIH HHS T32 AI052066NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

Commensal organisms that constitute the skin microbiota play a pivotal role in the orchestration of cutaneous homeostasis and immune competence. This balance can be promptly offset by the expansion of the opportunistic pathogen Staphylococcus aureus, which is responsible for the majority of bacterial skin infections. S. aureus carriage is also known to be a precondition for its transmission and pathogenesis. Recent reports suggest that skin-dwelling coagulase-negative staphylococci (CoNS) can prime the skin immune system to limit the colonization potential of invaders, and they can directly compete through production of antimicrobial molecules or through signaling antagonism. We review recent advances in these CoNS colonization resistance mechanisms, which may serve to aid development of pharmacologic and probiotic intervention strategies to limit S. aureus skin colonization and disease.

Indexed as

Host-Pathogen InteractionsMicrobial InteractionsHumansMicrobiotaSkinStaphylococcal Skin InfectionsStaphylococcusStaphylococcus aureuscolonizationhost protectionMRSAquorum sensingskin microbiotaStaphylococcus aureus

Identifiers

PMID30846311
PMCPMC7176043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.