Evidence map›Paper›PMID 30845997›Full record

ArticleNutrition journal2019

Dietary raisin intake has limited effect on gut microbiota composition in adult volunteers.

Akemi T Wijayabahu, Sheldon G Waugh, Maria Ukhanova, Volker Mai

Registry-linked trialAbstract read
In one paragraph

Article in Nutrition journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02713165 (Effects of Adding Raisins to the American Diet on Fecal Microbiota Composition), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02713165 nacompletednot on this map

Effects of Adding Raisins to the American Diet on Fecal Microbiota Composition

TypeinterventionalSponsorUniversity of FloridaRan2016 to 2016Enrolled18ConditionsInflammationArmsRaisins
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases.International journal of molecular sciences · 2023
    Review
  10. Review
  11. Review
  12. Dietary Polyphenol, Gut Microbiota, and Health Benefits.Antioxidants (Basel, Switzerland) · 2022
    Review
  13. IndigenousFoods (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Akemi T WijayabahuDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, USA.
Sheldon G WaughDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, USA.
Maria UkhanovaDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, USA.
Volker MaiDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, USA. vmai@ufl.edu.ORCID 0000-0002-6997-9750

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDried fruits, such as raisins, contain phytochemicals and dietary fibers that contribute to maintaining health, potentially at least partially through modification in gut microbiota composition and activities. However, the effects of raisin consumption on gut microbiota have not previously been thoroughly investigated in humans. Therefore, the objective of this study was to determine how adding three servings of sun dried raisin/day to the diet of healthy volunteers affects gut microbiota composition.

methodsA 14-day exploratory feeding study was conducted with thirteen healthy individuals between the ages of 18 and 59 years. Participants consumed three servings (28.3 g each) of sun dried raisins daily. Fecal samples were collected prior to raisin consumption (baseline) and after the addition of raisins to the diet (on days 7 and 14). To determine the effects of raisin intake, fecal microbiota composition before and after raisin consumption was characterized for each participant by 16S rRNA gene sequencing.

resultsOverall microbiota diversity was not significantly affected by adding raisins to the diet. However, upon addition of raisins to the diet specific OTUs matching Faecalibacterium prausnitzii, Bacteroidetes sp. and Ruminococcus sp. increased in prevalence while OTUs closest to Klebsiella sp., Prevotella sp. and Bifidobacterium spp. decreased.

conclusionOur findings suggest that adding raisins to the diet can affect the prevalence of specific bacterial taxa. Potential health benefits of the observed microbiota changes should be determined in future studies in populations for which specific health outcomes can be targeted.

trial registrationhttp://www.clinicaltrials.gov ; Identifier: NCT02713165 .

Indexed as

DietFood, PreservedFruitVitisAdultBacteriaDNAFecesFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedRNA, Ribosomal, 16SSequence Analysis, DNADNARNA, Ribosomal, 16SGut microbiotaHealthy adultsHumanSun dried raisins

Identifiers

PMID30845997
PMCPMC6404294

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.