Evidence map›Paper›PMID 30845995›Full record

ArticleBMC cancer2019

A multi-center prospective randomized controlled trial (phase III) comparing the quality of life between laparoscopy-assisted distal gastrectomy and totally laparoscopic distal gastrectomy for gastric Cancer (study protocol).

Chang Min Lee, Ji Ho Park, Chang In Choi, Han Hong Lee, Jae-Seok Min, Ye Seob Jee, Oh Jeong, Hyundong Chae, Sung Il Choi, Hua Huang and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03393182 (A Multicenter Randomized Controlled Trial Comparing the Quality of Life Between Laparoscopy-assisted Distal Gastrectomy and Totally Laparoscopic Distal Gastrectomy for Gastric cancer_KLASS 07), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03393182 nacompletednot on this map

A Multicenter Randomized Controlled Trial Comparing the Quality of Life Between Laparoscopy-assisted Distal Gastrectomy and Totally Laparoscopic Distal Gastrectomy for Gastric cancer_KLASS 07 (CKLASS01)(Korea-China Collaborated Study)

TypeinterventionalSponsorKorea University Anam HospitalRan2018 to 2022Enrolled443ConditionsQuality of Life, Gastric Cancer, Surgery, Surgical ComplicationArmsTLDG arm, LADG arm
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Morbidity and quality of life of totally laparoscopic versus laparoscopy-assisted distal gastrectomy for early gastric cancer: a multi-center prospective randomized controlled trial (CKLASS01).Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Trial
  3. Trial
  4. Article
  5. Current clinical trials on gastric cancer surgery in China.World journal of gastrointestinal oncology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Short- and long-term oncological outcomes of totally laparoscopic gastrectomy versus laparoscopy-assisted gastrectomy for clinical stage I gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021
    Article
  11. [Reconstruction following gastrectomy].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
    Review
  12. Article
  13. Progress of Gastric Cancer Surgery in the era of Precision Medicine.International journal of biological sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 3 countries.

Chang Min LeeDepartment of Surgery, Korea University College of Medicine, Seoul, Korea.
Ji Ho ParkDepartment of Surgery, Gyeongsang National University School of Medicine, Jinju, Korea.
Chang In ChoiDepartment of Surgery, Medical Research Institute, Pusan National Universtiy Hospital, Busan, Korea.
Han Hong LeeDepartment of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jae-Seok MinDepartment of Surgery, Dongnam Institute of Radiological and Medical Science, Busan, Korea.
Ye Seob JeeDepartment of Surgery, Dankook University College of Medicine, Cheonan, Korea.
Oh JeongDepartment of Surgery, Chonnam National University Medical School, Gwangju, Korea.
Hyundong ChaeDepartment of Surgery, Catholic University of Daegu School of Medicine, Daegu, Korea.
Sung Il ChoiDepartment of Surgery, Kyung Hee University Hospital at Gang Dong, Seoul, Korea.
Hua HuangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. huahuang@fudan.edu.cn.
Sungsoo ParkDepartment of Surgery, Korea University College of Medicine, Seoul, Korea. kugspss@korea.ac.kr.ORCID http://orcid.org/0000-0003-2643-2007
Korea University · KRCatholic University of Korea · KRChonnam National University · KRDaegu Catholic University · KRDankook University · KRDongnam Institute of Radiological & Medical Sciences · KRGyeongsang National University · KRKyung Hee University Hospital at Gangdong · KRPusan National University Hospital · KRShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKLASS (the Korean Laparoendoscopic Gastrointestinal Surgery Study) is a time-honored study group that has established laparoscopic surgery for gastrointestinal disease in Korea and has performed some important studies for the rationale of laparoscopic gastrointestinal surgery. A multi-center RCT (randomized controlled trial) to compare the quality of life (QOL) of patients undergoing totally laparoscopic distal gastrectomy (TLDG) and laparoscopy-assisted distal gastrectomy (LADG) for gastric cancer, named as KLASS 07, has been currently prepared in Korea.

methodsPatients diagnosed as gastric cancer, with clinical stage IA (T1N0M0) or IB (T1N1M0 / T2N0M0) according to the 7th edition of the Americal Joint Committee on Cancer System, were randomized to receive either TLDG or LADG. For surgical quality control, the surgeons participating in this trial had to have performed at least 50 gastrectomies and at least 30 gastrectomies annually (regardless of open or laparoscopic surgery for gastric cancer). The patients who are allocated to TLDG group undergo intracorporeal anastomosis and those who are assigned to LADG undergo extracorporeal anastomosis for gastrointestinal reconstruction. DISCUSSION: Thirty-one surgeons from 26 institutions were engaged in this trial. The primary endpoint is 30-day morbidity, and secondary endpoint is QOL assessed by the questionnaire score. The KLASS 07 trial is the first multi-center RCT to investigate whether there are significant and quantifiable differences between the QOL of TLDG and LADG. The findings from this trial are expected to be the critical clues for designing the detailed procedures during laparoscopic surgery for gastric cancer.

trial registrationThe protocol of KLASS 07 (CKLASS 01) was registered in http://register.clinicaltrials.gov as NCT03393182 (Date of registration: January 2nd, 2018.).

Indexed as

GastrectomyLaparoscopyQuality of LifeStomach NeoplasmsClinical Trials, Phase III as TopicCost-Benefit AnalysisHumansMorbidityMortalityMulticenter Studies as TopicRandomized Controlled Trials as TopicRepublic of KoreaTreatment OutcomeGastric cancerLaparoscopy-assisted distal gastrectomyRandomized controlled trialTotally laparoscopic distal gastrectomy

Identifiers

PMID30845995
PMCPMC6407283
OpenAlexW2924723283

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.