ArticleBMC ophthalmology2019
Evaluation of the ocular surface characteristics and Demodex infestation in paediatric and adult blepharokeratoconjunctivitis.
Article in BMC ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Preferred practice patterns and review on rosacea.Indian journal of ophthalmology · 2023Guideline
- Clinical characteristics and preliminary retrospective evidence of adjunctive efficacy of intense pulsed light therapy for Demodex-associated blepharokeratoconjunctivitis: a single-center study.Annals of medicine · 2026Article
- Clinical Characteristics, Management, and Visual Outcomes of Spontaneous Corneal Perforation: A Single-Center Retrospective Study in South Korea.Korean journal of ophthalmology : KJO · 2026Article
- In Vivo Confocal Microscopy Revealed Alteration of Limbal Stem Cells and Sub-Basal Nerve Plexus in Allergic and Dry Eye-Related Ocular Surface Diseases.Translational vision science & technology · 2026Article
- Advances in the Medical Management of Pediatric Blepharokeratoconjunctivitis.Advances in therapy · 2026Review
- Article
- Pediatric blepharokeratoconjunctivitis: findings and outcomes in Hispanic vs. Non-Hispanic patients.BMC ophthalmology · 2025Article
- Definition and Diagnostic Criteria for Pediatric Blepharokeratoconjunctivitis.JAMA ophthalmology · 2024Article
- The impact of ocular demodicosis on the eyes.Eye (London, England) · 2023Article
- Meibomian Gland Dysfunction Clinical Practice Guidelines.Japanese journal of ophthalmology · 2023Article
- Demodicosis in Different Age Groups and Alternative Treatment Options-A Review.Journal of clinical medicine · 2023Review
- Massive Demodicosis of the Eyes in a Patient with Sjögren Syndrome: A Case Report.Acta parasitologica · 2021Article
- Topical Steroids and Antibiotics for Adult Blepharokeratoconjunctivitis (BKC): A Meta-Analysis of Randomized Clinical Trials.Journal of ophthalmology · 2021Review
- Conjunctivitis in Dupilumab Clinical Trials for Adolescents with Atopic Dermatitis or Asthma.American journal of clinical dermatology · 2021Article
- Is there a relationship between keratoconus and ocularOman journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundTo evaluate the ocular surface characteristics and the infestation of Demodex in Chinese paediatric and adult blepharokeratoconjunctivitis (BKC).
methodsFifty consecutive patients with BKC and 50 age- and sex-matched healthy subjects were enrolled. Lid margin characteristics and corneal disorders were evaluated under slit-lamp illumination. Four eyelashes were collected from each eye to examine Demodex infestation by light microscopy.
resultsCorneal neovascularization (P = 0.001) and scarring (P = 0.040) were significantly worse in children than in adults with BKC, whereas meibum quality was worse in adults (P = 0.008). Diagnosis delay was longer in children with BKC than in adults (2.2 vs 1.2 years, P = 0.022). Demodex infestation was more frequent in subjects with BKC than in healthy subjects (56% vs 26%, P = 0.002). The lid margin inflammation and meibomian gland dysfunction were worse in Demodex-positive subjects than in Demodex-negative subjects with BKC.
conclusionsChildren with BKC had severer corneal disorders compared with adult BKC patients, which may be caused by a long-delayed diagnosis. Ocular demodicosis was more common in subjects with BKC. Ocular Demodex infestation was associated with worse lid margin inflammation and meibomian gland dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.