ArticleReproductive biology and endocrinology : RB&E2019
Should ICSI be implemented during IVF to all advanced-age patients with non-male factor subfertility?
Article in Reproductive biology and endocrinology : RB&E, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Does paternal age affect the live birth rate in donor oocyte cycles? A systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2023Pooled it
- The effect of ICSI in infertility couples with non-male factor: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2020Pooled it
- Indications for Micro-Injection of Sperm in Assisted Reproduction: A Consensus Statement.The Australian & New Zealand journal of obstetrics & gynaecology · 2026Article
- Insemination methods for embryos transferred in frozen-thawed embryo transfer cycles do not impact reproductive outcomes in couples with non-male factor infertility.Scientific reports · 2025Article
- Pregnancy and neonatal outcomes of intracytoplasmic sperm injection versus in vitro fertilization in fresh cycles of women with advanced maternal age and nonmale factor infertility: A cross-sectional study.International journal of reproductive biomedicine · 2025Article
- Article
- Secretomes from Conventional Insemination and Intra-Cytoplasmic Sperm Injection Derived Embryos Differentially Modulate Endometrial Cells In Vitro.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Sperm Preparation with Microfluidic Sperm Sorting Chip May Improve Intracytoplasmic Sperm Injection Outcomes Compared to Density Gradient Centrifugation.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- The relationship between microbial contaminations of embryo transfer catheters with pregnancy outcome after embryo transfer.Annals of medicine and surgery (2012) · 2023Article
- Should ICSI be implemented on patients with poor-quality embryos in the previous IVF cycle?Heliyon · 2023Article
- Clinical predictors of embryo quality among women of advanced age receiving intracytoplasmic sperm injection cycles in Malaysia: A cohort study.International journal of reproductive biomedicine · 2022Article
- Placental histology and pregnancy complications following intracytoplasmic sperm injection for non-male factor infertility.Journal of assisted reproduction and genetics · 2022Article
- The impact of maternal age on gene expression during the GV to MII transition in euploid human oocytes.Human reproduction (Oxford, England) · 2021Article
- More blastocysts are produced from fewer oocytes in ICSI compared to IVF - results from a sibling oocytes study and definition of a new key performance indicator.Reproductive biology and endocrinology : RB&E · 2021Article
- The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility-A Critical Review.Journal of clinical medicine · 2021Review
- Calcium Oscillatory Patterns and Oocyte Activation During Fertilization: a Possible Mechanism for Total Fertilization Failure (TFF) in Human In Vitro Fertilization?Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Comparison of in vitro fertilisation/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age.Journal of assisted reproduction and genetics · 2021Article
- Sperm DNA fragmentation index and high DNA stainability do not influence pregnancy success after intracytoplasmic sperm injection.F&S reports · 2020Article
- Evaluating the value of day 0 of an ICSI cycle on indicating laboratory outcome.Scientific reports · 2020Observational
- The Conundrum of Poor Ovarian Response: From Diagnosis to Treatment.Diagnostics (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroudIn order to maximize In vitro fertilization (IVF) success rates in advanced- age patients, it has been suggested to favor the use of intracytoplasmic sperm injection (ICSI) over conventional insemination (CI), with the notion that ICSI would serve as a tool to overcome interference in sperm oocyte interaction and sperm oocyte penetration issues that can be related to maternal age and are not due to sperm abnormalities. We therefore aim to evaluate the role of ICSI in the treatment of non-male factor infertile patients aged ≥35 in terms of fertilization and top-quality embryo rates.
methodsIn this retrospective cohort study, data were collected and analyzed for all patients with non-male factor infertility, aged ≥35 treated, undergoing their first IVF cycle attempt with 6 or more oocytes yield, in whom a 50% ICSI-CI division was performed.
resultsFive hundreds and four oocytes were collected from 52 eligible patients. Overall, 245 oocytes underwent ICSI and 259 oocytes underwent CI. The fertilization rate was 71.0% following ICSI, compared to 50.1% in the CI treated oocytes (P < 0.001). The top quality embryo rate was 62.8% following ICSI compared to 45.5% following CI (P < 0.001). Subdividing the study population to two age groups revealed that the above differences remained significant in patients aged 35-39 yrs., whereas in those aged 40-45 yrs., the differences were non-significant but still inclined in favor of ICSI.
conclusionsThis study favors the use of ICSI in the older IVF population in order to increase both the fertilization rate and the number of top quality embryos that result per IVF cycle. Further studies are needed to establish our observations and use ICSI as the preferred approach to overcome egg sperm abnormal interactions related to advanced maternal age.
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