Evidence map›Paper›PMID 30845926›Full record

ArticleBMC pulmonary medicine2019

Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population.

Diana A van der Plaat, Judith M Vonk, Lies Lahousse, Kim de Jong, Alen Faiz, Ivana Nedeljkovic, Najaf Amin, Cleo C van Diemen, Guy G Brusselle, Yohan Bossé and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Diana A van der PlaatDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700, RB, Groningen, The Netherlands.
Judith M VonkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700, RB, Groningen, The Netherlands.
Lies LahousseDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Kim de JongDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700, RB, Groningen, The Netherlands.
Alen FaizGroningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ivana NedeljkovicDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Najaf AminDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Cleo C van DiemenDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Guy G BrusselleDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Yohan BosséDepartment of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec, Canada.
Corry-Anke BrandsmaGroningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ke HaoMerck Research Laboratories, Boston, MA, USA.
Peter D ParéDepartment of Medicine, Center for Heart Lung Innovation and Institute for Heart and Lung Health, University of British Columbia, St. Paul's Hospital, Vancouver, Canada.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Dirkje S PostmaGroningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
H Marike BoezenDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700, RB, Groningen, The Netherlands. h.m.boezen@umcg.nl.ORCID http://orcid.org/0000-0002-4320-1481
University Medical Center Groningen · NLErasmus MC · NLGhent University Hospital · BEInstitut universitaire de cardiologie et de pneumologie de Québec · CAMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity of British Columbia · CA

Funding

Longfonds 4.1.13.007
6 · The paper itself

Abstract

backgroundAirflow obstruction is a hallmark of chronic obstructive pulmonary disease (COPD), and is defined as either the ratio between forced expiratory volume in one second and forced vital capacity (FEV

methodsGWASes were performed in the LifeLines Cohort Study for both airflow obstruction definitions in never-smokers (NS = 5071) and ever-smokers (ES = 4855). The FEV

resultsIn the LifeLines cohort, 96% and 93% of the never- and ever-smokers were classified concordantly based on the two definitions. 26 and 29% of the investigated SNPs were overlapping at p < 0.05 in never- and ever-smokers, respectively. At p < 10

conclusionsThe definition of airflow obstruction and the population under study may be important determinants of which SNPs are associated with airflow obstruction. The genes FABP7 and NFYC(-AS1) could play a role in airflow obstruction in never-smokers specifically.

Indexed as

Genome-Wide Association StudyAdolescentAdultAgedAged, 80 and overCCAAT-Binding FactorCohort StudiesFatty Acid-Binding Protein 7FemaleForced Expiratory VolumeGenes, OverlappingGenetic Predisposition to DiseaseHumansLinear ModelsLogistic ModelsLungCCAAT-Binding FactorFABP7 protein, humanFatty Acid-Binding Protein 7NFYC protein, humanTumor Suppressor ProteinsAirflow obstructionCOPDGeneticsGenome-wide association study

Identifiers

PMID30845926
PMCPMC6407273
OpenAlexW2920846185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.