ArticleDiagnostics (Basel, Switzerland)2019
4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores.
Article in Diagnostics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug-Drug Interactions.CPT: pharmacometrics & systems pharmacology · 2025Pooled it
- Plasma biomarkers of vitamin B6 homeostasis and the risk of stroke in individuals with type 2 diabetes: a nested case-control study.European journal of nutrition · 2026Article
- Metabolomic landscape of fetal organ development during late gestation in mice.Communications biology · 2025Article
- Enhancing Holstein steers growth performance: oregano essential oil's impact on rumen development, functionality and microorganism.Animal microbiome · 2025Article
- Untargeted metabolomics reveals distinct biomarkers and metabolic alterations in familial and non-genetic hypercholesterolemia in Saudi patients.Frontiers in medicine · 2025Article
- Association between vitamin BFrontiers in pediatrics · 2025Article
- Integration of bile proteomics and metabolomics analyses reveals novel insights into different types of gallstones in a high-altitude area.BMC gastroenterology · 2024Article
- Assessing and Monitoring Nutrition Security in the United States: A Narrative Review of Current Measures and Instruments.Current nutrition reports · 2024Review
- Genetic mutation and aqueous humor metabolites alterations in a family with Marfan syndrome.Heliyon · 2024Article
- Inulin Reduces Kidney Damage in Type 2 Diabetic Mice by Decreasing Inflammation and Serum Metabolomics.Journal of diabetes research · 2024Article
- Mediation of endothelial activation and stress index in the association between vitamin BFrontiers in nutrition · 2024Article
- Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.Clinical epigenetics · 2023Article
- Alterations in gut microbiota and urine metabolomics in infants with yin-deficiency constitution aged 0-2 years.Heliyon · 2023Article
- Metabolomics Combined with Transcriptomics Analysis Revealed the Amino Acids, Phenolic Acids, and Flavonol Derivatives Biosynthesis Network in DevelopingFoods (Basel, Switzerland) · 2022Article
- Therapeutic Effect and Mechanism of Si-Miao-Yong-An-Tang on Thromboangiitis Obliterans Based on the Urine Metabolomics Approach.Frontiers in pharmacology · 2022Article
- Intestinal microbiomics and liver metabolomics insights into the preventive effects of chromium (III)-enriched yeast on hyperlipidemia and hyperglycemia induced by high-fat and high-fructose diet.Current research in food science · 2022Article
- Ultra-Performance Liquid Chromatography-Mass Spectrometry-Based Untargeted Metabolomics Reveals the Key Potential Biomarkers for Castor Meal-Induced Enteritis in Juvenile Hybrid Grouper (Frontiers in nutrition · 2022Article
- UHPLC-MS-Based Serum and Urine Metabolomics Reveals the Anti-Diabetic Mechanism of Ginsenoside Re in Type 2 Diabetic Rats.Molecules (Basel, Switzerland) · 2021Article
- Workshop report: Toward the development of a human whole stool reference material for metabolomic and metagenomic gut microbiome measurements.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Effects of Genetic Variation on Urinary Small Molecule Signatures of Mice after Exposure to Ionizing Radiation: A Study of p53 Deficiency.Metabolites · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVascular diseases are multifactorial and several risk factors may have synergetic effect on the global vascular risk. Among patients with diabetes, we investigated whether vitamin B6 species differ according to global cardiovascular risk.
methodsThe present observational study included 122 patients with type 2 diabetes (mean (SD) age = 69.9 (9.1) years; 50% men). Concentrations of vitamin B6 vitamers were measured. Classical blood biomarkers and risk factors were used to compute a multivariate risk score.
resultsPlasma concentrations of 4-pyridoxic acid were higher in patients with high risk versus those with low risk scores (48.2 (63.7) vs. 31.9 (15.0) nmol/L;
conclusionVitamin B6 metabolism was shifted in patients with multiple vascular risk factors. The catabolism to 4-pyridoxic acid was enhanced, whereas the catabolism to pyridoxine was lowered. High 4-Pyridoxic acid/pyridoxine ratio is independently associated with global cardiovascular risk.
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