Evidence map›Paper›PMID 30845776›Full record

ArticleNutrients2019

Comparisons of Estimated Intakes and Plasma Concentrations of Selected Fatty Acids in Pregnancy.

Marie T B Madsen, Anne A Bjerregaard, Jeremy D Furtado, Thorhallur I Halldorsson, Marin Ström, Charlotta Granström, Edward Giovannucci, Sjurdur F Olsen

Open access · goldAbstract readValidation Study
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 4 countries.

Marie T B MadsenDepartment of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark. mtbm@ssi.dk.
Anne A BjerregaardDepartment of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark. ANNE@ssi.dk.
Jeremy D FurtadoDepartment of Nutrition, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. jfurtado@hsph.harvard.edu.
Thorhallur I HalldorssonDepartment of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark. LUR@ssi.dk.
Marin StrömDepartment of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark. MRM@ssi.dk.
Charlotta GranströmDepartment of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark. CGS@ssi.dk.
Edward GiovannucciDepartment of Nutrition, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. egiovann@hsph.harvard.edu.
Sjurdur F OlsenDepartment of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark. sfo@ssi.dk.
Statens Serum Institut · DKHarvard University · US

Funding

Danish Council for Independent Research 1331-00229A, 9601842 and 22-03-0536Health Foundation 11/263-96Heart Foundation 96-2-4-83-22450Innovation Fund Denmark 09-067124March of Dimes Foundation 6-FY-96-0240, 6-FY97-0553, 6-FY97-0521, 6-FY00-407Novo Nordisk Fonden 2010-11-12 and 2009-07-28
6 · The paper itself

Abstract

The growing interest in potential health effects of long-chain polyunsaturated fatty acids (PUFAs) makes it important to evaluate the method used to assess the fatty acid intake in nutrition research studies. We aimed to validate the questionnaire-based dietary intake of selected PUFAs: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), α-linolenic acid (ALA), linoleic acid (LA), and arachidonic acid (AA) within the Danish National Birth Cohort (DNBC), by comparing 345 women's reported intake with concentration of plasma biomarkers. The applied questionnaire- and biomarker data reflect dietary intake from around the same time point in mid-pregnancy and relationships were investigated by use of Pearson and Spearman correlation and linear regression statistics. We demonstrated moderate but consistent adjusted correlations between dietary intake estimates and the corresponding plasma biomarker concentrations (differences in plasma concentration per 100 mg/day greater intake of 0.05 (95% CI: 0.02; 0.08)) and 0.05 (95% CI: 0.01; 0.08) percentage of total plasma fatty acids for EPA and DHA, respectively). The associations strengthened when restricting the analyses to women with ALA intake below the median intake. We found a weak correlation between the dietary intake of ALA and its plasma biomarker with a difference in plasma concentration of 0.07 (95% CI: 0.03; 0.10) percent of total plasma fatty acids per 1 g/day greater intake, while the dietary intake of LA and AA did not correlate with their corresponding biomarkers.

Indexed as

Adultalpha-Linolenic AcidBiomarkersDenmarkDietDietary Fats, UnsaturatedDiet SurveysDocosahexaenoic AcidsEatingEicosapentaenoic AcidFatty Acids, UnsaturatedFemaleHumansLinear ModelsLinoleic AcidMaternal Serum Screening Testsalpha-Linolenic AcidBiomarkersDietary Fats, UnsaturatedDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, UnsaturatedLinoleic AcidbiomarkersDanish National Birth CohortFFQfood frequency questionnaireLCn3FAslong-chained n-3 fatty acidspolyunsaturated fatty acidpregnancy dietPUFAsvalidation study

Identifiers

PMID30845776
PMCPMC6470916
OpenAlexW2919933267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.