Evidence map›Paper›PMID 30845767›Full record

ArticleInternational journal of molecular sciences2019

In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C.

Nushrat Yasmin, Yoichi Ishitsuka, Madoka Fukaura, Yusei Yamada, Shuichi Nakahara, Akira Ishii, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Niemann-Pick Disease Type C (NPDC) by Mutation ofAntioxidants (Basel, Switzerland) · 2023
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Understanding and Treating Niemann-Pick Type C Disease: Models Matter.International journal of molecular sciences · 2020
    Review
  9. Cyclic Oligosaccharides as Active Drugs, an Updated Review.Pharmaceuticals (Basel, Switzerland) · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Nushrat YasminDepartment of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. nushratyasmin@gmail.com.
Yoichi IshitsukaDepartment of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. y-zuka@gpo.kumamoto-u.ac.jp.
Madoka FukauraDepartment of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. 171y2002@st.kumamoto-u.ac.jp.
Yusei YamadaDepartment of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. 162y3101@st.kumamoto-u.ac.jp.ORCID 0000-0001-9652-2919
Shuichi NakaharaDepartment of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. 126p1031@st.kumamoto-u.ac.jp.
Akira IshiiDepartment of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. 161p2001@st.kumamoto-u.ac.jp.
Yuki KondoDepartment of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. ykondo@kumamoto-u.ac.jp.ORCID 0000-0003-1456-7721
Toru TakeoDivision of Reproductive Engineering, Center for Animal Resources and Development (CARD), Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan. takeo@kumamoto-u.ac.jp.ORCID 0000-0002-8103-651X
Naomi NakagataDivision of Reproductive Engineering, Center for Animal Resources and Development (CARD), Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan. nakagata@gpo.kumamoto-u.ac.jp.
Keiichi MotoyamaDepartment of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. motoyama@gpo.kumamoto-u.ac.jp.
Taishi HigashiDepartment of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. higashit@kumamoto-u.ac.jp.
Yasuyo OkadaInstitute Biosciences, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan. okada@mukogawa-u.ac.jp.
Junichi NishikawaInstitute Biosciences, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan. nisikawa@mukogawa-u.ac.jp.
Atsushi IchikawaInstitute Biosciences, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan. aichikaw@mukogawa-u.ac.jp.
Daisuke IoharaLaboratory of Physical Pharmaceutics, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan. dio@ph.sojo-u.ac.jp.
Fumitoshi HirayamaLaboratory of Physical Pharmaceutics, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan. fhira@ph.sojo-u.ac.jp.
Katsumi HigakiDivision of Functional Genomics, Research Center for Bioscience and Technology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan. kh4060@med.tottori-u.ac.jp.
Kousaku OhnoSanin Rosai Hospital, 1-8-1, Kaikeshinden, Yonago 683-8605, Japan. ohno@sanmedia.or.jp.
Muneaki MatsuoDepartment of Pediatrics, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan. matsuo@cc.saga-u.ac.jp.ORCID 0000-0002-8667-836X
Tetsumi IrieDepartment of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. tirie@gpo.kumamoto-u.ac.jp.
Kumamoto University · JPMukogawa Women's University · JPSojo University · JPSaga University · JPSanin Rosai Hospital · JPTottori University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niemann-Pick disease Type C (NPC) is a rare lysosomal storage disease characterized by the dysfunction of intracellular cholesterol trafficking with progressive neurodegeneration and hepatomegaly. We evaluated the potential of 6-

Indexed as

Animalsbeta-CyclodextrinsCHO CellsCholesterolCricetinaeCricetulusDisease Models, AnimalDose-Response Relationship, DrugInjections, SubcutaneousMiceNiemann-Pick C1 ProteinNiemann-Pick Disease, Type CNuclear Magnetic Resonance, BiomolecularTreatment Outcome6-O-maltosyl-beta-cyclodextrinbeta-CyclodextrinsCholesterolNiemann-Pick C1 Protein2-hydroxypropyl-β-cyclodextrin6-O-α-maltosyl-β-cyclodextrincyclodextrinNiemann-Pick disease type C

Identifiers

PMID30845767
PMCPMC6429330
OpenAlexW2920125937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.