Evidence map›Paper›PMID 30845734›Full record

ArticleMolecules (Basel, Switzerland)2019

Evolution and Biological Evaluation of Matrinic Derivatives with Amantadine Fragments As New Anti-Influenza Virus Agents.

Tianyu Niu, Xiaoqiang Zhao, Jing Jiang, Haiyan Yan, Yinghong Li, Sheng Tang, Yuhuan Li, Danqing Song

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianyu NiuBeijing Key Laboratory of Anti-infective Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 10005, China. niutianyubasn@163.com.
Xiaoqiang ZhaoBeijing Key Laboratory of Anti-infective Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 10005, China. xiaoqiangzhao@126.com.
Jing JiangBeijing Key Laboratory of Anti-infective Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 10005, China. 18299093210@163.com.
Haiyan YanBeijing Key Laboratory of Anti-infective Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 10005, China. yan0495@163.com.
Yinghong LiBeijing Key Laboratory of Anti-infective Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 10005, China. liyinghong@imb.pumc.edu.cn.
Sheng TangBeijing Key Laboratory of Anti-infective Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 10005, China. tang13874204108@163.com.
Yuhuan LiBeijing Key Laboratory of Anti-infective Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 10005, China. yuhuanlibj@126.com.
Danqing SongBeijing Key Laboratory of Anti-infective Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 10005, China. songdanqingsdq@hotmail.com.

Funding

CAMS initiative for innovative medicine 2016-12M-3-009the National Natural Science Foundation of China 81502934the National Natural Science Foundation of China 81621064
6 · The paper itself

Abstract

A series of novel tricyclic matrinic derivatives with 11-adamantyl substitution were designed, synthesized, and evaluated for their activities against Influenza A H3N2 virus, based on the privileged structure strategy. Structure-activity relationship (SAR) analysis indicated that the introduction of an 11-adamantyl might be helpful for the potency. Among them, compounds

Indexed as

AmantadineAnimalsAntiviral AgentsCell SurvivalDogsDrug Evaluation, PreclinicalDrug StabilityFemaleHumansInfluenza A Virus, H3N2 SubtypeInfluenza, HumanMadin Darby Canine Kidney CellsMiceMolecular StructureStructure-Activity RelationshipAmantadineAntiviral Agentsanti-virusH3N2influenza A virusstructure–activity relationshiptricyclic matrinic derivatives

Identifiers

PMID30845734
PMCPMC6429159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.