Evidence map›Paper›PMID 30845727›Full record

ArticleCells2019

Physiological Expression of Ion Channel Receptors in Human Periodontal Ligament Stem Cells.

Luigi Chiricosta, Francesca Diomede, Oriana Trubiani, Placido Bramanti, Emanuela Mazzon

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Luigi ChiricostaIRCCS Centro Neurolesi "Bonino-Pulejo", 98124 Messina, Italy. luigi.chiricosta@irccsme.it.ORCID 0000-0003-0358-7348
Francesca DiomedeDepartment of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. francesca.diomede@unich.it.ORCID 0000-0002-0384-6509
Oriana TrubianiDepartment of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. trubiani@unich.it.ORCID 0000-0002-7459-4898
Placido BramantiIRCCS Centro Neurolesi "Bonino-Pulejo", 98124 Messina, Italy. placido.bramanti@irccsme.it.
Emanuela MazzonIRCCS Centro Neurolesi "Bonino-Pulejo", 98124 Messina, Italy. emanuela.mazzon@irccsme.it.
Centro Neurolesi Bonino Pulejo · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The etiopathogenesis of neurodegenerative diseases is characterized by the death of neurons. Human periodontal ligament stem cells (hPDLSCs), coming from neuronal crest, can potentially become neuronal cells because of their embryologic origin. In this study, we performed an RNA-seq analysis of hPDLSCs in order to determine whether their transcriptomic profile revealed genes encoded for ion channel receptors. Next, each found gene was enriched by the information of pathways stored in the Reactome database. Our results show that the hPDLSCs express

Indexed as

AdultCell Differentiationgamma-Aminobutyric AcidGene Expression RegulationGlutamic AcidHumansIon ChannelsMaleModels, BiologicalPeriodontal LigamentReceptors, Cell SurfaceStem Cellsgamma-Aminobutyric AcidGlutamic AcidIon ChannelsReceptors, Cell Surfaceacethylcoline receptorGABAB receptorhuman periodontal ligament stem cellnext generation sequencingRNA-seqtranscriptome analysis

Identifiers

PMID30845727
PMCPMC6468776
OpenAlexW2918477414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.