Evidence map›Paper›PMID 30845695›Full record

ArticleCancers2019

Anatomic Origin of Osteochondrogenic Progenitors Impacts Sensitivity to EWS-FLI1-Induced Transformation.

Elise R Pfaltzgraff, April Apfelbaum, Andrew P Kassa, Jane Y Song, Wei Jiang, Tahra K Suhan, Deneen M Wellik, Elizabeth R Lawlor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Unlocking epigenetics for precision treatment of Ewing's sarcoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024
    Article
  3. Article
  4. EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Elise R PfaltzgraffDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA. erpfaltz@umich.edu.
April ApfelbaumDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA. aapfelba@umich.edu.
Andrew P KassaDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA. apkassa@umich.edu.
Jane Y SongCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA. janeys@umich.edu.
Wei JiangDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA. weijian@umich.edu.
Tahra K SuhanDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA. tahraklu@umich.edu.ORCID 0000-0002-5918-6511
Deneen M WellikDepartment of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, MI 48109, USA. wellik@wisc.edu.
Elizabeth R LawlorDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA. elawlor@umich.edu.
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3M
Role of Hox Genes in Integration of the Musculoskeletal System in Development R01AR061402 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI WELLIK, DENEEN M · 2011 to 2021
$3.3M
Regulation and function of HOX genes in Ewing sarcoma pathogenesisR01CA215981 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAWLOR, ELIZABETH R · 2018 to 2022
$2.0M
Investigating developmental Hox programs as determinants of sarcomagenesisR21CA215968 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAWLOR, ELIZABETH R, WELLIK, DENEEN M · 2017 to 2018
$372k
Alex's Lemonade Stand Foundation for Childhood Cancer innovation grantNCI NIH HHS P30 CA046592NCI NIH HHS R01 CA215981NCI NIH HHS R21 CA215968NCI NIH HHS T32 CA 009676NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR061402NIDCR NIH HHS T32 DE00007057-40NIDCR NIH HHS T32 DE00007057-41
6 · The paper itself

Abstract

Ewing sarcomas predominantly arise in pelvic and stylopod bones (i.e., femur and humerus), likely as a consequence of

Indexed as

cell of originEwing sarcomaHoxmesenchymal progenitor cellsMSCs

Identifiers

PMID30845695
PMCPMC6468467
OpenAlexW2920756182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.